Physiotherapy - Reviews Open access

Efficacy of positive expiratory pressure in the prevention and treatment of postoperative pulmonary complications following thoracic and abdominal surgery. A systematic review and meta-analysis

Authors

Published
4 February 2026
Section
Physiotherapy - Reviews

Abstract

Postoperative pulmonary complications (PPCs), including atelectasis, pneumonia, and respiratory failure, are common after thoracic and upper abdominal surgery and are associated with increased morbidity, longer hospital stays, and higher costs. This systematic review and meta-analysis investigated whether positive expiratory pressure (PEP) devices reduce PPCs after thoracic or upper abdominal surgery compared with continuous positive airway pressure (CPAP), usual care/no intervention, or other non-CPAP respiratory treatments. We searched major databases and included randomized controlled trials. A total of 12 studies were included, and 7 contributed to the meta-analysis. Across comparator-stratified analyses, PEP did not demonstrate a consistent reduction in PPCs. Compared with usual care/no intervention, pooled estimates showed no significant benefit, and results were similarly inconclusive when PEP was compared with other non-CPAP treatments; evidence vs. CPAP was limited to a single small trial. The overall certainty of evidence was low due to methodological limitations and heterogeneity in outcome definitions and intervention protocols. Overall, current evidence does not support routine use of PEP devices as a primary strategy to prevent PPCs after thoracic or upper abdominal surgery. Further well-designed trials are needed to clarify whether specific patient subgroups or standardized protocols may benefit.

References

  1. Warner DO. Preventing postoperative pulmonary complications: the role of the anesthesiologist. Anesthesiology 2000;92:1467-72. DOI: https://doi.org/10.1097/00000542-200005000-00037
  2. Agostini P, Cieslik H, Rathinam S, et al. Postoperative pulmonary complications following thoracic surgery: are there any modifiable risk factors? Thorax 2010;65:815-8. DOI: https://doi.org/10.1136/thx.2009.123083
  3. Serpa Neto A, Hemmes SN, Barbas CS, et al. Incidence of mortality and morbidity related to postoperative lung injury in patients who have undergone abdominal or thoracic surgery: a systematic review and meta-analysis. Lancet Respir Med 2014;2:1007-15. DOI: https://doi.org/10.1016/S2213-2600(14)70228-0
  4. Lusquinhos J, Tavares M, Abelha F. Postoperative pulmonary complications and perioperative strategies: a systematic review. Cureus. 2023;15:e38786. DOI: https://doi.org/10.7759/cureus.38786
  5. LAS VEGAS investigators. Epidemiology, practice of ventilation and outcome for patients at increased risk of postoperative pulmonary complications: LAS VEGAS – an observational study in 29 countries. Eur J Anaesthesiol 2017;34:492-507. DOI: https://doi.org/10.1097/EJA.0000000000000646
  6. Canet J, Gallart L, Gomar C, et al. Prediction of postoperative pulmonary complications in a population-based surgical cohort. Anesthesiology 2010;113:1338-50. DOI: https://doi.org/10.1097/ALN.0b013e3181fc6e0a
  7. Orman J, Westerdahl E. Chest physiotherapy with positive expiratory pressure breathing after abdominal and thoracic surgery: a systematic review. Acta Anaesthesiol Scand 2010;54:261-7. DOI: https://doi.org/10.1111/j.1399-6576.2009.02143.x
  8. McIlwaine M, Button B, Nevitt SJ. Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis. Cochrane Database Syst Rev 2019;11:CD003147. DOI: https://doi.org/10.1002/14651858.CD003147.pub5
  9. Andrews J, Sathe NA, Krishnaswami S, et al. Nonpharmacologic airway clearance techniques in hospitalized patients: a systematic review. Respir Care 2013;58:2160-86. DOI: https://doi.org/10.4187/respcare.02704
  10. Christensen EF, Schultz P, Jensen OV, et al. Postoperative pulmonary complications and lung function in high-risk patients: a comparison of three physiotherapy regimens after upper abdominal surgery in general anesthesia. Acta Anaesthesiol Scand 1991;35:97-104. DOI: https://doi.org/10.1111/j.1399-6576.1991.tb03255.x
  11. Pieczkoski SM, de Oliveira AL, Haeffner MP, et al. Positive expiratory pressure in postoperative cardiac patients in intensive care: a randomized controlled trial. Clin Rehabil 2021;35:681-91. DOI: https://doi.org/10.1177/0269215520972701
  12. Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 2021;372:n71. DOI: https://doi.org/10.1136/bmj.n71
  13. Sterne JAC, Savović J, Page MJ, et al. RoB 2: a revised tool for assessing risk of bias in randomized trials. BMJ 2019;366:l4898. DOI: https://doi.org/10.1136/bmj.l4898
  14. Ricksten SE, Bengtsson A, Soderberg C, et al. Effects of periodic positive airway pressure by mask on postoperative pulmonary function. Chest 1986;89:774-81. DOI: https://doi.org/10.1378/chest.89.6.774
  15. Frølund L, Madsen F. Self-administered prophylactic postoperative positive expiratory pressure in thoracic surgery. Acta Anaesthesiol Scand 1986;30:381-5. DOI: https://doi.org/10.1111/j.1399-6576.1986.tb02435.x
  16. Westerdahl E, Lindmark B, Almgren SO, Tenling A. Chest physiotherapy after coronary artery bypass graft surgery: a comparison of three different deep breathing techniques. J Rehabil Med 2001;33:79-84. DOI: https://doi.org/10.1080/165019701750098920
  17. Westerdahl E, Lindmark B, Eriksson T, et al. Deep-breathing exercises reduce atelectasis and improve pulmonary function after coronary artery bypass surgery. Chest 2005;128:3482-8. DOI: https://doi.org/10.1378/chest.128.5.3482
  18. Rotolo N, Cattoni M, D’Andria M, et al. Comparison of an expiratory flow accelerator device versus positive expiratory pressure for tracheobronchial airway clearance after lung cancer lobectomy: a preliminary study. Physiotherapy 2021;110:34-41. DOI: https://doi.org/10.1016/j.physio.2019.01.011
  19. Fagevik Olsén M, Wennberg E, Johnsson E, et al. Randomized clinical study of the prevention of pulmonary complications after thoracoabdominal resection by two different breathing techniques. Br J Surg 2002;89:1228-34. DOI: https://doi.org/10.1046/j.1365-2168.2002.02207.x
  20. Ingwersen UM, Larsen KR, Bertelsen MT, et al. Three different mask physiotherapy regimens for prevention of post-operative pulmonary complications after heart and pulmonary surgery. Intensive Care Med 1993;19:294-8. DOI: https://doi.org/10.1007/BF01690551
  21. Richter Larsen K, Ingwersen U, Thode S, Jakobsen S. Mask physiotherapy in patients after heart surgery: a controlled study. Intensive Care Med 1995;21:469-74. DOI: https://doi.org/10.1007/BF01706199
  22. Fagevik Olsén M, Hahn I, Nordgren S, et al. Randomized controlled trial of prophylactic chest physiotherapy in major abdominal surgery. Br J Surg 1997;84:1535-8. DOI: https://doi.org/10.1111/j.1365-2168.1997.02828.x
  23. Westerdahl E, Lindmark B, Eriksson T, et al. The immediate effects of deep breathing exercises on atelectasis and oxygenation after cardiac surgery. Scand Cardiovasc J 2003;37:363-7. DOI: https://doi.org/10.1080/14017430310014984
  24. Matte P, Jacquet L, Van Dyck M, Goenen M. Effects of conventional physiotherapy, continuous positive airway pressure and non-invasive ventilatory support with bilevel positive airway pressure after coronary artery bypass grafting. Acta Anaesthesiol Scand 2000;44:75-81. DOI: https://doi.org/10.1034/j.1399-6576.2000.440114.x
  25. Ferreyra GP, Baussano I, Squadrone V, et al. Continuous positive airway pressure for treatment of respiratory complications after abdominal surgery: a systematic review and meta-analysis. Ann Surg 2008;247:617-26. DOI: https://doi.org/10.1097/SLA.0b013e3181675829
  26. Miskovic A, Lumb AB. Postoperative pulmonary complications. Br J Anaesth 2017;118:317-34. DOI: https://doi.org/10.1093/bja/aex002
  27. Campbell I, Waterhouse J. Applied respiratory physiology. Anaesth Intensive Care Med 2005;6:371-5. DOI: https://doi.org/10.1383/anes.2005.6.11.371
  28. Hedenstierna G, Edmark L. Mechanisms of atelectasis in the perioperative period. Best Pract Res Clin Anaesthesiol 2010;24:157-69. DOI: https://doi.org/10.1016/j.bpa.2009.12.002
  29. Magnusson L, Spahn DR. New concepts of atelectasis during general anaesthesia. Br J Anaesth 2003;91:61-72. DOI: https://doi.org/10.1093/bja/aeg085
  30. Lagier D, Zeng C, Fernandez-Bustamante A, Vidal Melo MF. Perioperative pulmonary atelectasis: part II. Clinical implications. Anesthesiology 2022;136:206-36. DOI: https://doi.org/10.1097/ALN.0000000000004009
  31. Saraswat V. Effects of anaesthesia techniques and drugs on pulmonary function. Indian J Anaesth 2015;59:557-64. DOI: https://doi.org/10.4103/0019-5049.165850
  32. Jimenez-Santana JD, Azzolina D, Scaramuzzo G, et al. Ultrasound-detected postoperative diaphragmatic dysfunction and its association with pulmonary complications. A systematic review and meta-analysis. J Clin Anesth 2025;107:112027. DOI: https://doi.org/10.1016/j.jclinane.2025.112027
  33. Saliba KA, Blackstock F, McCarren B, Tang CY. Effect of positive expiratory pressure therapy on lung volumes and health outcomes in adults with chest trauma: a systematic review and meta-analysis. Phys Ther 2022;102:pzab254. DOI: https://doi.org/10.1093/ptj/pzab254
  34. Santos MD, Milross MA, Eisenhuth JP, Alison JA. Pressures and oscillation frequencies generated by bubble-positive expiratory pressure devices. Respir Care 2017;62:444-50. DOI: https://doi.org/10.4187/respcare.05164
  35. American Association for Respiratory Care. AARC clinical practice guideline: use of positive airway pressure adjuncts to bronchial hygiene therapy. Respir Care 1993;38:516-21. DOI: https://doi.org/10.1177/194336549303800513

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