Pneumology - Original Articles
30 July 2025
Early Access
https://doi.org/10.4081/monaldi.2025.3433

Evaluating hematological and inflammatory biomarkers in tuberculosis management

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Tuberculosis, inflammatory biomarkers, C-reactive protein, anemia in TB, hematological markers
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Sanatkumar Bharamu Nyamagoud
https://orcid.org/0000-0002-5111-7685
Department of Pharmacy Practice, KLE College of Pharmacy, Vidyanagar, Hubballi, Karnataka, India.
Princy Domnic Dsouza
princydsouza1012@gmail.com
Department of Pharmacy Practice, KLE College of Pharmacy, Vidyanagar, Hubballi, Karnataka, India.
Sai Phalguna Prakash Chitralu
Department of Pharmacy Practice, KLE College of Pharmacy, Vidyanagar, Hubballi, Karnataka, India.
Kadambari Solankure
https://orcid.org/0000-0002-3740-6931
Department of Kriya Sharir Kaher’s Shri B M Kankanwadi Ayurveda Mahavidyalaya Shahapur, Belagavi, Karnataka, India.
Agadi Hiremath Viswanatha Swamy
Department of Pharmacy Practice, KLE College of Pharmacy, Vidyanagar, Hubballi, Karnataka, India.

Tuberculosis (TB) remains a significant public health concern, particularly in resource-limited settings. Accurate and timely diagnosis and effective monitoring of disease progression and treatment response remain a challenge. This research aims to evaluate the function of hematological and inflammatory biomarkers, including hemoglobin (HB), serum amyloid A (SAA), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and white blood cell (WBC) count, in TB patients. Overall, 80 TB patients were analyzed to evaluate the association of these biomarkers with disease status and demographic characteristics. The findings revealed significant alterations in inflammatory markers, with elevated WBC, SAA, CRP, and ESR levels, indicating an ongoing inflammatory response. Additionally, decreased HB levels were observed, suggesting the presence of anemia, which is commonly associated with chronic infections such as TB. Pearson's correlation analysis revealed a significant negative connection between HB and inflammatory markers, reinforcing the link between anemia and TB-associated inflammation. However, no noteworthy associations were found between biomarker levels and demographic parameters, including age and gender, residence, or treatment duration. These findings emphasize the potential utility of these biomarkers in TB diagnosis, prognosis, and treatment monitoring, especially in regions where advanced diagnostic tools are not readily available. The study suggests that routine hematological and inflammatory markers can serve as cost-effective adjunctive tools in TB administration. Additional investigation is needed to confirm these results and determine their role in predicting treatment outcomes and disease severity.

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Ethics approval

The study's objectives were thoroughly explained to the patients and their families to ensure a clear understanding. KLE College of Pharmacy Ethical Committee granted ethical approval for the study (IEC Reference Number: KLECOPH/IEC/2024-25/08).

How to Cite



“Evaluating Hematological and Inflammatory Biomarkers in Tuberculosis Management”. 2025. Monaldi Archives for Chest Disease, July. https://doi.org/10.4081/monaldi.2025.3433.
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