Pneumology - Original Articles
12 September 2025

The role of counseling in maintaining blood sugar control in patients with pulmonary tuberculosis and diabetes mellitus

Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
131
Views
62
Downloads

Authors

Diabetes mellitus (DM) has emerged as an important comorbidity associated with tuberculosis (TB). Both diseases are known to affect each other’s course. There has not been much data on the impact of frequent blood sugar monitoring and counseling in patients with TB and DM. A study was therefore conducted to assess the effects of these measures on glycemic control, radiological improvement, and treatment outcomes. A total of 50 sputum-positive pulmonary TB and DM patients were enrolled and divided into 2 groups (A and B) of 25 patients each. Blood sugar monitoring in both groups was done at the initiation of treatment, at the end of the intensive phase (IP), and at the end of the continuation phase (CP), and they were counseled for glycemic control. Additionally, group A patients were counseled weekly in the IP and biweekly in the CP for glycemic control. Group B patients were provided with glucometers and told to record blood sugars weekly during the IP and biweekly in the CP. The radiological improvement was measured using the TIMIKA score, and treatment outcome was assigned based on end CP sputum conversion. The mean age of groups A and B was 52.96±11.06 years and 51.6±13.05 years, respectively. The differences between the mean fasting blood sugar (FBS) and TIMIKA scores of the two groups at treatment initiation, end IP, and end CP were statistically non-significant (p=0.986, 0.70, and 0.650, and p=0.190, 0.156, and 0.214, respectively). When the two groups were compared for changes in mean FBS status and TIMIKA score from start to end IP, end IP to end CP, and start to end CP, the changes were again statistically non-significant (p=0.171, p=0.076, p=0.541, and p=0.892, p=0.691, p=0.461, respectively). The final treatment outcomes of the two groups were also similar (p=1.000) Counseling of patients with TB and DM was found to be similar to frequent blood glucose monitoring, as no statistically significant differences in the two groups concerning improvement in blood sugar levels, radiological changes, and treatment outcomes were found. It is hence proposed that dedicated counseling sessions are effective and should be a part of routine care in TB patients with DM.

Altmetrics

Downloads

Download data is not yet available.

Citations

Chakaya J, Khan M, Ntoumi F, et al. Global tuberculosis report 2020—reflections on the global TB burden, treatment and prevention efforts. Int J Infect Dis 2021;113:S7-12. DOI: https://doi.org/10.1016/j.ijid.2021.02.107
Baker MA, Harries AD, Jeon CY, et al. The impact of diabetes on tuberculosis treatment outcomes: a systematic review BMC Med 2011;9:81. DOI: https://doi.org/10.1186/1741-7015-9-81
McMurry HS, Mendenhall E, Rajendrakumar A, et al. Coprevalence of type 2 diabetes mellitus and tuberculosis in low-income and middle-income countries: a systematic review. Diabetes Metab Res Rev 2019;35:e3066. DOI: https://doi.org/10.1002/dmrr.3066
India Tuberculosis-Diabetes Study Group. Screening of patients with tuberculosis for diabetes mellitus in India. Trop Med Int Health 2013;18:636-45. DOI: https://doi.org/10.1111/tmi.12084
Ruslami R, Koesoemadinata RC, Soetedjo NNM, et al. The effect of a structured clinical algorithm on glycemic control in patients with combined tuberculosis and diabetes in Indonesia: A randomized trial. Diabetes Res Clin Pract 2021;173:108701. DOI: https://doi.org/10.1016/j.diabres.2021.108701
Koesoemadinata RC, McAllister SM, Soetedjo NNM, et al. Educational counselling of patients with combined TB and diabetes mellitus: a randomised trial. Public Health Action 2021;11:202-8. DOI: https://doi.org/10.5588/pha.21.0064
Riza AL, Pearson F, Ugarte-Gil C, et al. Clinical management of concurrent diabetes and tuberculosis and the implications for patient services. Lancet Diabetes Endocrinol 2014;2:740-53. DOI: https://doi.org/10.1016/S2213-8587(14)70110-X
Sherwani SI, Khan HA, Ekhzaimy A, et al. Significance of HbA1c test in diagnosis and prognosis of diabetic patients. Biomark Insights 2016;11:95-104. DOI: https://doi.org/10.4137/BMI.S38440
Udaykumar P, Kumar S, Chandralekha N, et al. Daily monitoring of diabetic treatment amongst TB-DM patients under NTEP: does it improve the treatment outcomes? Clin Epidemiol Glob Health 2022;17:101118. DOI: https://doi.org/10.1016/j.cegh.2022.101118
Thiel BA, Bark CM, Nakibali JG, et al. Reader variability and validation of the Timika X-ray score during treatment of pulmonary tuberculosis. Int J Tuberc Lung Dis 2016;20:1358-63. DOI: https://doi.org/10.5588/ijtld.16.0186
Chakraborthy A, Shivananjaiah AJ, Ramaswamy S, Chikkavenkatappa N. Chest X ray score (Timika score): an useful adjunct to predict treatment outcome in tuberculosis. Adv Respir Med 2018;86:205-10. DOI: https://doi.org/10.5603/ARM.2018.0032
WHO. Guidance for national tuberculosis programmes on the management of tuberculosis in children. 2nd edition. 2014. Available from: https://iris.who.int/bitstream/handle/10665/112360/9789241548748_eng.pdf.
Saalai KM, Mohanty A. The effect of glycemic control on clinico-radiological manifestations of pulmonary tuberculosis in patients with diabetes mellitus. Int J Mycobacteriol 2021;10:268-70. DOI: https://doi.org/10.4103/ijmy.ijmy_133_21
Zhan S, Juan X, Ren T, et al. Extensive radiological manifestation in patients with diabetes and pulmonary tuberculosis: a cross-sectional study. Ther Clin Risk Manag 2022;18:595-602. DOI: https://doi.org/10.2147/TCRM.S363328
Reis-Santos B, Locatelli R, Horta BL, et al. Socio-demographic and clinical differences in subjects with tuberculosis with and without diabetes mellitus in Brazil--a multivariate analysis. PLoS One 2013;8:e62604. DOI: https://doi.org/10.1371/journal.pone.0062604
Kibirige D, Andia-Biraro I, Olum R, et al. Tuberculosis and diabetes mellitus comorbidity in an adult Ugandan population. BMC Infect Dis 2024;24:242. DOI: https://doi.org/10.1186/s12879-024-09111-8
Religioni U, Barrios-Rodríguez R, Requena P, et al. Enhancing therapy adherence: impact on clinical outcomes, healthcare costs, and patient quality of life. Medicina 2025;61:153. DOI: https://doi.org/10.3390/medicina61010153
Selda C, Feride TY, Seval G, Meryem T. The effect of nursing counseling on treatment compliance: acute coronary syndrome and diabetes mellitus. J Nurs Res 2024;32:e339. DOI: https://doi.org/10.1097/jnr.0000000000000621
Dailey G, Kim MS, Lian JF. Patient compliance and persistence with antihyperglycemic drug regimens: evaluation of a Medicaid patient population with type 2 diabetes mellitus. Clin Ther 2001;23:1311-20. DOI: https://doi.org/10.1016/S0149-2918(01)80110-7
K V N, Duraisamy K, Balakrishnan S, et al. Outcome of tuberculosis treatment in patients with diabetes mellitus treated in the revised national tuberculosis control programme in Malappuram district, Kerala, India. PLoS One 2013;8:e76275. DOI: https://doi.org/10.1371/journal.pone.0076275
Khanna A, Lohya S, Sharath BN, Harries AD. Characteristics and treatment response in patients with tuberculosis and diabetes mellitus in New Delhi, India. Public Health Action 2013;3:S48-50. DOI: https://doi.org/10.5588/pha.13.0025
Mily A, Sarker P, Taznin I, et al. Slow radiological improvement and persistent low-grade inflammation after chemotherapy in tuberculosis patients with type 2 diabetes. BMC Infect Dis 2020;20:933. DOI: https://doi.org/10.1186/s12879-020-05473-x
Tegegne BS, Mengesha MM, Teferra AA, et al. Association between diabetes mellitus and multi-drug-resistant tuberculosis: evidence from a systematic review and meta-analysis. Syst Rev 2018;7:161. DOI: https://doi.org/10.1186/s13643-018-0828-0

Ethics approval

The study was approved by the institute’s Ethics committee [letter no. 9(310)2022/38577 dated 13/12/22].

How to Cite



“The Role of Counseling in Maintaining Blood Sugar Control in Patients With Pulmonary Tuberculosis and Diabetes Mellitus”. 2025. Monaldi Archives for Chest Disease, September. https://doi.org/10.4081/monaldi.2025.3418.