Cardiology - Original Articles
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https://doi.org/10.4081/monaldi.2025.3390

Coronary plaques and pericardial fat volume assessment in patients with metabolic syndrome being evaluated for suspected coronary artery disease

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Received: 28 January 2025
Accepted: 4 May 2025
Published: 3 December 2025
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Metabolic syndrome, pericardial fat, coronary atherosclerosis, plaque, angiography

Authors

Abdulameer A. Al-Mosawi
https://orcid.org/0000-0002-5730-7383
Radiology Department, Medicine College, University of Kufa, Najaf, Iraq.
Hussein Nafakhi
husseinaf.alnaffakh@uokufa.edu.iq
https://orcid.org/0000-0002-0238-0460
Internal Medicine Department, Medicine College, University of Kufa, Najaf, Iraq.
Wasan Kadhum Abbas
https://orcid.org/0009-0005-4791-3653
Radiology Department, Al-Manara College for Medical Sciences, Amarah city, Maysan Governorate, Iraq.
Hayder Nafakhi
https://orcid.org/0009-0002-0337-3198
Medicine College, University of Kufa, Najaf, Iraq.

The relationship between increased pericardial fat volume (PFV) and coronary plaque characteristics in patients with metabolic syndrome (MetS) is unclear. We aimed to assess PFV and coronary plaque characteristics, including type, stenosis severity, and presence of multiple plaques, among patients with MetS being evaluated for suspected coronary artery disease (CAD). This retrospective study included patients with suspected CAD who underwent computed tomography coronary angiography to exclude the presence of occlusive CAD. MetS diagnosis was based on the American Association of Clinical Endocrinologists criteria. The study included 811 individuals with suspected CAD who underwent MDCT examinations: 127 were in the MetS group, 71 were in the diabetes mellitus (DM) group, and 613 were in the control group (neither DM nor MetS). PFV was higher in the MetS group compared to the DM and the control groups (p=0.003). The MetS group had a higher prevalence of multiple (p<0.001) and mixed coronary plaques (p<0.001) compared to other groups. Increased age [odds ratio (OR) confidence interval (CI)=1.1(1-1.2), p=0.039] and PFV [OR (CI)=1 (1-1.2), p=0.027] showed an independent association with multiple plaque presence, while PFV was an independent predictor of mixed plaque presence [OR (CI)=1.1 (1-1.2), p=0.008]. In conclusion, patients with MetS had larger PFV and a higher prevalence of mixed and multiple coronary plaques than patients without MetS. PFV showed an independent and significant association with mixed and multiple coronary plaques among patients with MetS.

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Ethics Approval

This retrospective study was approved by Ethical Committee for Clinical Studies at the Faculty of Medicine, University of Kufa under approval number MEC-30/42024.

How to Cite



“Coronary Plaques and Pericardial Fat Volume Assessment in Patients With Metabolic Syndrome Being Evaluated for Suspected Coronary Artery Disease”. 2025. Monaldi Archives for Chest Disease, December. https://doi.org/10.4081/monaldi.2025.3390.
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