Cardiology - Original Articles
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https://doi.org/10.4081/monaldi.2025.3306

Unveiling atrial electromechanical delay in chronic obstructive pulmonary disease: an observational cohort study from north India

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Received: 16 December 2024
Accepted: 30 March 2025
Published: 1 December 2025
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Atrial electromechanical delay, chronic obstructive pulmonary disease, atrial fibrillation, cardiovascular outcomes, P wave dispersion

Authors

Ratesh Buhlan
https://orcid.org/0009-0002-4037-5723
Department of Tuberculosis and Respiratory Diseases, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Arjun Tandon
https://orcid.org/0000-0003-1545-1069
Department of Cardiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Mohit Bhatia
https://orcid.org/0009-0001-4962-6456
Department of Tuberculosis and Respiratory Diseases, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Atul Tiwari
Department of Tuberculosis and Respiratory Diseases, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Soumik Ghosh
soumik13joy@gmail.com
https://orcid.org/0000-0002-5119-8809
Department of Cardiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
J. K. Mishra
Department of Tuberculosis and Respiratory Diseases, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

Chronic obstructive pulmonary disease (COPD) is often associated with cardiovascular complications such as atrial fibrillation (AF), heart failure, and myocardial infarction. AF is highly prevalent in COPD, yet the mechanisms linking them remain unclear. This study investigates the role of atrial electromechanical delay (AEMD) in predicting cardiovascular outcomes in COPD patients. This prospective cohort study included 60 COPD patients (forced expiratory volume in 1 second/forced vital capacity <0.7) from August 2022 to March 2024. Patients with pre-existing heart disease and other major comorbidities were excluded. Participants underwent spirometry, electrocardiogram (ECG), echocardiography, and N-terminal pro b-type natriuretic peptide (NT-proBNP) testing. AEMD was measured at the lateral and medial mitral annuli and tricuspid annulus. Primary endpoints included AF incidence, heart failure, stroke, and COPD exacerbations, while secondary endpoints were hospitalization and mortality. AEMD values were significantly higher in patients with AF (75.4±5.9 ms vs. 70.4±4.1 ms, p=0.004), heart failure, and COPD exacerbations, particularly at the lateral and medial mitral annuli. AEMD at the tricuspid annulus was strongly associated with mortality (p=0.04). P wave dispersion (41.2±6.4 ms vs. 36.1±4.2 ms, p=0.001) and QT dispersion (49.3±8.9 ms vs. 42.1±6.8 ms, p=0.002) were significantly elevated in patients with adverse outcomes. Elevated NT-proBNP levels (>1000 pg/mL) correlated with prolonged AEMD, suggesting cardiac stress. AEMD, particularly at the mitral and tricuspid annuli, is a strong predictor of AF, heart failure, and COPD exacerbations. P wave and QT dispersion are associated with increased hospitalization and mortality, highlighting their role in risk stratification. These findings support the use of AEMD and ECG parameters as early markers for cardiovascular complications in COPD. Further validation in larger cohorts is needed.

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Ethics Approval

The study protocol was approved by the Institutional Ethics Committee of Institute of Medical Sciences, Banaras Hindu University, Varanasi (Approval Number: [Dean/2022/EC/5056], Dated: 15.04.2023).

How to Cite



“Unveiling Atrial Electromechanical Delay in Chronic Obstructive Pulmonary Disease: An Observational Cohort Study from North India”. 2025. Monaldi Archives for Chest Disease, December. https://doi.org/10.4081/monaldi.2025.3306.
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