Pneumology - Reviews
1 September 2025
Early Access
Fetal-maternal complications due to pregnancy-acquired tuberculosis: a narrative review of the literature
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
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Tuberculosis (TB) during pregnancy can cause certain deleterious effects to both the mother and the fetus, leading to significant morbidity and mortality. The risk of TB rises significantly during pregnancy due to dampening of the immune response in females and certain factors yet to be studied. Since pregnant females are ruled out of clinical trials due to their pregnancy status, not much clinical data is available on how to combat TB in them or about the clinical safety and efficacy of certain drugs. Hence, not only is it important to make pregnant females vital study participants of clinical trials, but also to enhance their knowledge regarding the disease so that they may timely access quality care. It is also important to facilitate these TB-positive pregnant females through the introduction of gender-sensitive policies that are more exclusive and allow access to quality TB control programs that provide timely care, nutritional support, and quality and supportive management.
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Khoza LB, Mulondo SA, Lebese RT. Perspectives on pregnant women's educational needs to prevent TB complications during pregnancy and the neonatal period. A qualitative study. BMC Public Health 2023;23:1997. DOI: https://doi.org/10.1186/s12889-023-16770-w
Sundaram K, Vajravelu LK. Tuberculosis and its clinical consequences on women's health. Indian J Tuberc 2024;71:195-203. DOI: https://doi.org/10.1016/j.ijtb.2023.06.002
Hui SYA, Lao TT. Tuberculosis in pregnancy. Best Pract Res Clin Obstet Gynaecol 2022;85:34-44. DOI: https://doi.org/10.1016/j.bpobgyn.2022.07.006
Mathad JS, Yadav S, Vaidyanathan A, et al. Tuberculosis infection in pregnant people: current practices and research priorities. Pathogens 2022;1:1481. DOI: https://doi.org/10.3390/pathogens11121481
Marais BJ, Amanullah F, Gupta A, et al. Tuberculosis in children, adolescents, and women. Lancet Respir Med 2020;8:335-7. DOI: https://doi.org/10.1016/S2213-2600(20)30077-1
Miele K, Morris SB, Tepper NK. Tuberculosis in pregnancy. O bstetric Gynecol 2020;135:1444-53. DOI: https://doi.org/10.1097/AOG.0000000000003890
Knoledge Hub. The first national TB prevalence survey. South Africa. 2018. Short Report. Available from: https://knowledgehub.health.gov.za/elibrary/first-national-tb-prevalence-survey-south-africa-2018#:~:text=South%20Africa%20(SA)%20is%20one,for%203%25%20of%20cases%20globally .
Sobhy S, Babiker Z, Zamora J, et al. Maternal and perinatal mortality and morbidity associated with tuberculosis during pregnancy and the postpartum period: a systematic review and meta-analysis. BJO G 2017;124:727-33. DOI: https://doi.org/10.1111/1471-0528.14408
Dennis EM, Hao Y, Tamambang M, et al. Tuberculosis during pregnancy in the United States: racial/ethnic disparities in pregnancy complications and in-hospital death. PLoS O ne 2018;13;e0194836. DOI: https://doi.org/10.1371/journal.pone.0194836
El-Messidi A, Czuzoj-Shulman N, Spence AR, Abenhaim HA. Medical and obstetric outcomes among pregnant women with tuberculosis: a population-based study of 7.8 million births. Am J Obstet Gynecol 2016;215:797.e1-e6. DOI: https://doi.org/10.1016/j.ajog.2016.08.009
Lewis PF, Budhewar AS, Bavdekar NB. Fetomaternal outcome of pregnant women infected with tuberculosis: an analytical study. J South Asian Feder O bst Gynae 2021;13:197201. DOI: https://doi.org/10.5005/jp-journals-10006-1948
Sun Q , Zhang H, Zhang Y, et al. Increased risk of stillbirth among women whose partner has tuberculosis. BioMed Res Int 2021;2021:1837881. DOI: https://doi.org/10.1155/2021/1837881
Mathad JS, Gupta A. Tuberculosis in pregnant and postpartum women: epidemiology, management, and research gaps. Clin Infect Dis 2012;55:1532-49.
McArthur E, Bali S, Khan AA. Socio-cultural and knowledge-based barriers to tuberculosis diagnosis for women in Bhopal, India. Indian J Community Med 2016;41:62-4. DOI: https://doi.org/10.4103/0970-0218.170990
Adhikari M. Tuberculosis and tuberculosis/HIV co-infection in pregnancy. Sem Fetal Neonatal Med 2009;14:234-40. DOI: https://doi.org/10.1016/j.siny.2009.02.001
Mulondo SA, Khoza LB, Maputle SM. Factors associated with underutilisation of antenatal care services by pregnant women in Limpopo province, South Africa. Br J Midwifery 2020;28:788-95. DOI: https://doi.org/10.12968/bjom.2020.28.11.788
Gupta A, Hughes MD, Garcia-Prats AJ, et al. Inclusion of key populations in clinical trials of new antituberculosis treatments: current barriers and recommendations for pregnant and lactating women, children, and HIV-infected persons. PLoS Med 2019;16:e1002882. DOI: https://doi.org/10.1371/journal.pmed.1002882
Gupta A, Mathad JS, Abdel-Rahman SM, et al. Toward earlier inclusion of pregnant and postpartum women in tuberculosis drug trials: consensus statements from an international expert panel. Clin Infect D is 2016;62:761-9. DOI: https://doi.org/10.1093/cid/civ991
Sreeramareddy CT, Q in ZZ, Satyanarayana S, et al. Delays in diagnosis and treat- ment of pulmonary tuberculosis in India: a systematic review. Int J Tuberc Lung D is 2014;18:255-66. DOI: https://doi.org/10.5588/ijtld.13.0585
Vijay S, Kumar P, Chauhan LS, et al. Risk factors associated with default among new smear positive TB patients treated Under D O TS in India. PloS O ne 2010;5:e10043. DOI: https://doi.org/10.1371/journal.pone.0010043
Mukerji R, Turan JM. Challenges in accessing and utilising health services for women accessing D O TS TB services in Kolkata, India. Glob Public Health 2020;15:1718-29. DOI: https://doi.org/10.1080/17441692.2020.1751235
Jejeebhoy SJ, Sathar ZA. Women’s autonomy in India and Pakistan: the influence of religion and region. Popul Dev Rev 27:687-712. DOI: https://doi.org/10.1111/j.1728-4457.2001.00687.x
Krishnan L, Akande T, Shankar AV, et al. Gender- related barriers and delays in accessing tuberculosis diagnostic and treatment services: a systematic review of quali- tative studies. Tuberc Res Treat 2014;2014:215059. DOI: https://doi.org/10.1155/2014/215059
Courtwright A, Turner AN. Tuberculosis and stigmatization: pathways and interventions. Public Health Rep 2010;125:34-42. DOI: https://doi.org/10.1177/00333549101250S407
StopTB.org. A rapid assessment of gender and tuberculosis in India (2018). Available from: https://stoptb.org/assets/documents/communities/CRG/TB%20Gender%20Assessment%20Ind ia.pdf.
Mathad JS, Gupta A. Tuberculosis in pregnant and postpartum women: epidemiology, management, and research gaps. Clin Infect D is 2012;55:1532-49. DOI: https://doi.org/10.1093/cid/cis732
Bates M, Ahmed Y, Kapata N, et al. Perspectives on tuberculosis in pregnancy. Int J Infect D is 2015;32:124-7. DOI: https://doi.org/10.1016/j.ijid.2014.12.014
Palacios E, D allman R, Muñoz M, et al. D rug-resistant tuberculosis and pregnancy: treatment outcome of 38 cases in Lima, Peru. Clin Infect D is 2009;48:1413-9. DOI: https://doi.org/10.1086/598191
Loto O M, Awowole I. Tuberculosis in pregnancy: a review. J Pregnancy 2012;2012:379271. DOI: https://doi.org/10.1155/2012/379271
WHO. Guidelines for intensified tuberculosis case finding and isoniazide preventive therapy for people living with HIV in resource-constrained settings. Available from: https://iris.who.int/bitstream/handle/10665/44472/9789241500708_eng.pdf.
How to Cite
“Fetal-Maternal Complications Due to Pregnancy-Acquired Tuberculosis: A Narrative Review of the Literature”. 2025. Monaldi Archives for Chest Disease, September. https://doi.org/10.4081/monaldi.2025.3126.
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