https://doi.org/10.4081/monaldi.2024.2685

Evaluation of the effectiveness of Tadalafil on improving pulmonary function and asthma severity in severe asthmatic patients: a randomized controlled trial study

Early Access
Submitted: June 27, 2023
Accepted: November 21, 2023
Published: January 11, 2024
Tadalafil, asthma, quality of life, pulmonary function tests
Abstract Views: 482
PDF_EARLY VIEW: 140
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Authors

Seyed Hamid Borsi
Air Pollution and Respiratory Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Seyed Ali Asghar Fakhr Mousavi Fakhr Mousavi
Air Pollution and Respiratory Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Mehrdad Dargahi Mal-Amir
https://orcid.org/0000-0001-9300-9810
Air Pollution and Respiratory Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Heshmatollah Tavakol
Air Pollution and Respiratory Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Hanieh Raji
dr.raji.h@gmail.com
Air Pollution and Respiratory Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Phosphodiesterase inhibitors elevate the levels of cyclic adenosine monophosphate and cyclic guanosine monophosphate, which have been associated with various anti-inflammatory effects that can help alleviate asthma symptoms. This study aims to assess the impact of Tadalafil, a selective phosphodiesterase inhibitor, on pulmonary function in patients with asthma. This study was a randomized, double-blind clinical trial conducted in 2021 at Imam Khomeini Hospital in Ahvaz, Iran. The study enrolled 44 patients with severe asthma, who were divided equally into a Tadalafil group and a placebo group. The Tadalafil group received 20 mg/day of Tadalafil, while the placebo group received a placebo at the same dose. The patients' spirometry tests, asthma quality of life questionnaire, 6-minute walk distance, and quality of life were measured at the beginning of the study and one month later. The study results indicated that there was no statistically significant difference between the Tadalafil group and the placebo group in terms of pulmonary parameters (p>0.05). Furthermore, the scores for patients' quality of life (p=0.167) and the 6-minute walk test (p=0.148) at the end of the study did not show any statistically significant improvement compared to the placebo group. Results showed that the use of Tadalafil (20 mg) once daily for one month in patients with severe asthma did not affect clinical and laboratory outcomes.

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Ethics approval

This study was approved by the Medical Ethics Committee of Ahvaz Jundishapur University of Medical Sciences (Ethics code IR.AJUMS.REC.1398.920).

How to Cite

Borsi, Seyed Hamid, Seyed Ali Asghar Fakhr Mousavi Fakhr Mousavi, Mehrdad Dargahi Mal-Amir, Heshmatollah Tavakol, and Hanieh Raji. 2024. “Evaluation of the Effectiveness of Tadalafil on Improving Pulmonary Function and Asthma Severity in Severe Asthmatic Patients: A Randomized Controlled Trial Study”. Monaldi Archives for Chest Disease, January. https://doi.org/10.4081/monaldi.2024.2685.
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