https://doi.org/10.4081/monaldi.2023.2667

Differences in nutritional status of patients with chronic obstructive pulmonary disease between Mediterranean and non-Mediterranean regions in Croatia

Vol. 94 No. 3 (2024)
Submitted: June 16, 2023
Accepted: August 29, 2023
Published: September 13, 2023
Nutritional status, chronic obstructive pulmonary disease, bioelectrical impedance, obesity, Mediterranean region, continental region
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Authors

Davorka Muršić
https://orcid.org/0000-0002-0793-3343
University Hospital Centre Zagreb, Clinic for Lung Diseases Jordanovac, Zagreb, Croatia.
Tajana Jalušić Glunčić
https://orcid.org/0009-0002-9046-7175
University Hospital Centre Zagreb, Clinic for Lung Diseases Jordanovac, Zagreb, Croatia.
Jelena Ostojić
https://orcid.org/0000-0002-0314-331X
University Hospital Centre Zagreb, Clinic for Lung Diseases Jordanovac, Zagreb, Croatia.
Sanda Škrinjarić Cincar
https://orcid.org/0000-0003-2353-0656
Faculty of Medicine, University of Osijek, Croatia.
Ljiljana Bulat Kardum
https://orcid.org/0000-0003-2807-0927
Department of Pulmonology, Clinical Hospital Centre Rijeka, Croatia.
Martina Dokoza
https://orcid.org/0009-0003-3976-4665
Department of Internal Medicine, Zadar General Hospital, Croatia.
Nataša Karamarković Lazarušić
https://orcid.org/0000-0001-7773-3753
Polyclinic for the Respiratory Tract Diseases, Zagreb, Croatia.
Erim Bešić
https://orcid.org/0000-0002-1116-4655
Faculty of Pharmacy and Biochemistry, University of Zagreb, Croatia.
Miroslav Samaržija
https://orcid.org/0000-0001-5303-9353
University Hospital Centre Zagreb, Clinic for Lung Diseases Jordanovac, Zagreb; School of Medicine, University of Zagreb, Croatia.
Andrea Vukić Dugac
adugac71@gmail.com
https://orcid.org/0000-0002-1522-3325
University Hospital Centre Zagreb, Clinic for Lung Diseases Jordanovac, Zagreb; School of Medicine, University of Zagreb, Croatia.

The nutritional status of patients with chronic obstructive pulmonary disease (COPD) is a significant factor that influences the prognosis of the disease. This observational study aimed to analyze the nutritional status of COPD patients and assess the associations between nutritional status, disease severity, and exercise capacity in four different regions of Croatia. In this multicenter study, 534 COPD patients were recruited and evaluated concerning fat-free mass (FFM), FFM index (FFMI), skeletal muscle mass index (SMMI), phase angle (PhA), pulmonary function tests, and the 6-minute walk test (6MWT). There were 325 (60.9%) male and 209 (39.1%) female patients with a mean age of 66.7±8.4 years. Most patients (73.2%) exhibited a moderate to severely abnormal obstructive pattern and had a reduced 6MWT distance (396.5±110.8 m). Among the participants, 32.8% were overweight and 22.3% were obese, and they had satisfactory values for nutritional status variables (FFM, FFMI, SMMI, PhA). There were no statistical differences between the centers in terms of nutritional status variables. There was a significantly positive correlation of forced expiratory volume in one second with body mass index (BMI) (r=0.148, p=0.001), PhA (r=0.256, p=0.00), FFM (r=0.365, p=0.00), and SMMI (r=0.238, p=0.00). However, there was no significant correlation of the 6MWT with BMI (r=-0.049, p=0.254), FFM (r=0.065, p=0.133), and SMMI (r=-0.007, p=0.867). The data analysis demonstrated that our patients were not underweight and that there was no significant difference between the centers in terms of BMI, FFM, FFMI, SMMI, and PhA. This lack of significant difference was observed even though one of the regions studied was Mediterranean.

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Ethics Approval

The study protocol was approved by the Ethical Review Committee of the University of University Hospital Centre Zagreb (ID 02/18 AG) as well as by the Ethical Committee of the University Hospital Centre Rijeka, the University Hospital Centre Osijek and Zadar General Hospital.

How to Cite

Muršić, Davorka, Tajana Jalušić Glunčić, Jelena Ostojić, Sanda Škrinjarić Cincar, Ljiljana Bulat Kardum, Martina Dokoza, Nataša Karamarković Lazarušić, Erim Bešić, Miroslav Samaržija, and Andrea Vukić Dugac. 2023. “Differences in Nutritional Status of Patients With Chronic Obstructive Pulmonary Disease Between Mediterranean and Non-Mediterranean Regions in Croatia”. Monaldi Archives for Chest Disease 94 (3). https://doi.org/10.4081/monaldi.2023.2667.
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