Pleural effusion and Waldenström macroglobulinemia: if cytology and flow cytometric findings do not match. A case report
Abstract
Pleural effusion is a rare complication of lymphoplasmacytic lymphoma. When it occurs, traditional investigation techniques may not always be successful. Flow cytometry is a fast and precise diagnostic technique that can be helpful in the diagnosis of pleural localization of hematological diseases. We present a case report of pleural localization of Waldenström macroglobulinemia detected by flow cytometry.
References
- Gertz MA. Waldenström macroglobulinemia: 2019 update on diagnosis, risk stratification, and management, Am J Hematol 2019;94:266-76.
- Banwait R, Aljawai Y, Cappuccio J, et al. Extramedullary Waldenström macroglobulinemia. Am J Hematol 2015;90:100-4.
- Gustine JN, Meid K, Hunter ZR, et al. MYD88 mutations can be used to identify malignant pleural effusions in Waldenström macroglobulinaemia. Br J Haematol 2018;180:578-81.
- Mansoor A, Wagner RP, DePalma L. Waldenstrom macroglobulinemia presenting as a pleural effusion. Arch Pathol Lab Med 2000;124:891-3.
- Arora P, Gupta SK, Mallik N, et al. Flow cytometry in diagnosis of myelomatous pleural effusion: a case report. Indian J Hematol Blood Transfus 2016;32:S138-42.
- Chen H, Li P, Xie Y, et al. Cytology and clinical features of myelomatous pleural effusion: Three case reports and a review of the literature. Diagn Cytopathol 2018;46:604-9.
- Herold NC, Mitra P. Immunophenotyping. Treasure Island: StatPearls Publishing; 2023.
- Keklik M, Sivgin S, Pala C, et al. Flow cytometry method as a diagnostic tool for pleural fluid involvement in a patient with multiple myeloma. Mediterr J Hematol Infect Dis 2012;4:e2012063.
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