https://doi.org/10.4081/monaldi.2023.2655

Aortic root diameter, main pulmonary artery diameter/aortic root diameter and pericardial fat volume as predictors of occlusive coronary artery disease

Vol. 94 No. 2 (2024)
Submitted: July 24, 2023
Accepted: August 16, 2023
Published: September 13, 2023
Aortic root, pericardial fat, coronary artery disease, pulmonary artery, multi-detector computed tomography
Abstract Views: 815
PDF: 85
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

Abdulameer A. Al-Mosawi
Radiology Department, Medicine College, University of Kufa, Najaf, Iraq.
Hussein Nafakhi
husseinaf.alnaffakh@uokufa.edu.iq
https://orcid.org/0000-0002-0238-0460
Internal Medicine Department, Medicine College, University of Kufa, Najaf, Iraq.
Hadeel K. Hameed
https://orcid.org/0009-0006-9039-0082
Radiology Department, Medicine College, University of Kufa, Najaf, Iraq.

The clinical relevance of aortic root diameter (ARD), main pulmonary artery diameter (MPAd), or pericardial fat volume (PFV) in the assessment of coronary artery disease (CAD) is largely unknown. We aimed to assess the relationship of PFV, ARD, MPAd, and MPAd/ARD ratio with occlusive CAD (stenosis >50%).This cross-sectional study included patients who had chest pain suggestive of CAD and underwent a 64-multislice multi-detector computed tomography angiography exam to exclude occlusive CAD presence. A total of 145 patients were enrolled in this study. The mean age was 54±10 years, and 51% were males. The mean PFV, ARD, MPAd, and MPAd/ARD ratio in all patients were 155 cm3, 29.9 mm, 23.4 mm, and 0.8, respectively. On univariate analysis, PFV [odds ratio (OR) (confidence interval, CI)=1.1 (1.01-1.3), p<0.01], ARD [OR (CI)=1.2 (1.1-1.4), p<0.01], and MPAd/ARD ratio [OR (CI)= 0.2 (0.1-0.5), p=0.02] showed significant association with occlusive CAD presence. After adjusting for cardiac risk factors, only PFV [OR (CI)=1.1 (1.02-1.3), p<0.01], but not ARD [OR (CI)=0.9(0.3-2), p=0.85] or MPAd/ARD ratio [OR (CI)=0.1(0.1-2), p=0.69], was independently associated with occlusive CAD. In conclusion, increased PFV, but not ARD or MPAd/ARD ratio, showed a significant and independent association with occlusive CAD presence in patients with chest pain suggestive of CAD.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

Crossref
Scopus
Google Scholar
Europe PMC
Yu W, Liu B, Zhang F, et al. Association of epicardial fat volume with increased risk of obstructive coronary artery disease in Chinese patients with suspected coronary artery disease. J Am Heart Assoc 2021;10:e018080.
Von Krüchten R, Lorbeer R, Peters A, et al. Association between large arteries diameter and heart function in subjects free of cardiovascular diseases. J Pers Med 2022;12:889.
Fletcher AJ, Syed MBJ, Aitman TJ, et al. Inherited thoracic aortic disease: new insights and translational targets. Circulation 2020;141:1570-87.
Kholaif N, Mohamed TI, Alharbi IS, et al. Management and clinical outcomes of patients with homozygous familial hypercholesteremia in Saudi Arabia. Monaldi Arch Chest Dis 2023;93:2503.
Chung KS, Kim YS, Kim SK, et al. Functional and prognostic implications of the main pulmonary artery diameter to aorta diameter ratio from chest computed tomography in Korean COPD patients. PLoS One 2016;11:e0154584.
Nakanishi R, Rana JS, Shalev A, et al. Mortality risk as a function of the ratio of pulmonary trunk to ascending aorta diameter in patients with suspected coronary artery disease. Am J Cardiol 2013;111:1259-63.
Truong QA, Massaro JM, Rogers IS, et al. Reference values for normal pulmonary artery dimensions by noncontrast cardiac computed tomography: the Framingham Heart Study. Circ Cardiovasc Imaging 2012;5:147-54.
Karakus G, Kammerlander AA, Aschauer S, et al. Pulmonary artery to aorta ratio for the detection of pulmonary hypertension: cardiovascular magnetic resonance and invasive hemodynamics in heart failure with preserved ejection fraction. J Cardiovasc Magn Reson 2015;17:79.
Villasante Fricke AC, Iacobellis G. Epicardial adipose tissue: clinical biomarker of cardio-metabolic risk. Int J Mol Sci 2019;20:5989.
Nafakhi H, Al-Mosawi AA, Mudhafar MM. Pericardial fat versus BMI in the assessment of coronary atherosclerotic burden in patients with diabetes mellitus. Acta Diabetol 2020;57:605-11.
Chang SH, Chu PH, Tsai CT, et al. Both epicardial and peri-aortic adipose tissue blunt heart rate recovery beyond body fat mass. Front Cardiovasc Med 2022;9:939515.
Tarsitano MG, Pandozzi C, Muscogiuri G, et al. Epicardial adipose tissue: a novel potential imaging marker of comorbidities caused by chronic inflammation. Nutrients 2022;14:2926.
Ding J, Hsu FC, Harris TB, et al. The association of pericardial fat with incident coronary heart disease: the multi-ethnic study of atherosclerosis (MESA). Am J Clin Nutr 2009;90:499-504.
Mazurek T, Zhang L, Zalewski A, et al. Human epicardial adipose tissue is a source of inflammatory mediators. Circulation 200318;108:2460-6.
Wang Q, Chi J, Wang C, et al. Epicardial adipose tissue in patients with coronary artery disease: a meta-analysis. J Cardiovasc Dev Dis 2022;9:253.
Dogan C, Bayram Z, Efe SC, et al. Prognostic value of main pulmonary artery diameter to ascending aorta diameter ratio in patients with advanced heart failure. Acta Cardiol 2021;76:1108-16.
Nguyen-Thu H, Ohyama Y, Taketomi-Takahashi A, et al. Pulmonary artery diameter (PAD) and the pulmonary artery to aorta ratio (PAD/AAD) as assessed by non-contrast cardiac CT: the association with left ventricular (LV) remodeling and the LV function. Intern Med 2022;61:1809-15.
Sheikhzadeh S, De Backer J, Gorgan NR, et al. The main pulmonary artery in adults: a controlled multicenter study with assessment of echocardiographic reference values, and the frequency of dilatation and aneurysm in Marfan syndrome. Orphanet J Rare Dis 2014;9:203.
Lai CL, Chien KL, Hsu HC, et al. Aortic root dimension as an independent predictor for all-cause death in adults <65 years of age (from the Chin-Shan community cardiovascular cohort study). Echocardiography 2010;27:487-95.
Gardin JM, Arnold AM, Polak J, et al. Usefulness of aortic root dimension in persons > or = 65 years of age in predicting heart failure, stroke, cardiovascular mortality, all-cause mortality and acute myocardial infarction (from the cardiovascular health study). Am J Cardiol 2006;97:270-5.
Cuspidi C, Facchetti R, Bombelli M, et al. Aortic root diameter and risk of cardiovascular events in a general population: data from the PAMELA study. J Hypertens 2014;32:1879-87.
Tadic M, Gherbesi E, Sala C, et al. Is thoracic aortic diameter an independent predictor of cardiovascular disease and mortality? A narrative review. Front Cardiovasc Med 2022;9:867026.
Zheng X, Deng YJ, Han FG, et al. Assessment of thoracic aorta in different cardiac phases in patients with non-aorta diseases using cardiac CT. Sci Rep 2021;11:15209.

Ethics Approval

Approval of this study was provided by the IRB of the Medicine College, University of Kufa, Najaf (Iraq) with approval number (MEC-012021).

How to Cite

Al-Mosawi, Abdulameer A., Hussein Nafakhi, and Hadeel K. Hameed. 2023. “Aortic Root Diameter, Main Pulmonary Artery Diameter Aortic Root Diameter and Pericardial Fat Volume As Predictors of Occlusive Coronary Artery Disease”. Monaldi Archives for Chest Disease 94 (2). https://doi.org/10.4081/monaldi.2023.2655.
Copyright (c) 2023 The Author(s) Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.