https://doi.org/10.4081/monaldi.2023.2488

When benign leiomyomas metastasize to the lungs - a case report

Vol. 93 No. 4 (2023)
Submitted: November 19, 2022
Accepted: January 23, 2023
Published: February 3, 2023
Benign metastasizing leiomyoma (BML), pulmonary nodules, myomectomy
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Authors

Joana Vieira Naia
joanavnaia@gmail.com
https://orcid.org/0000-0002-6947-1148
Pulmonology Department, Hospital of Braga, Portugal.
Diana Pimenta
Pulmonology Department, Hospital of Braga, Portugal.
Anita Paiva
Pulmonology Department, Hospital of Braga, Portugal.
Rita Costa
https://orcid.org/0000-0001-7831-8711
Thoracic Surgery Department, University Hospital Center of São João, Porto, Portugal.
Conceição Souto de Moura
Pathology Department, University Hospital Center of São João, Porto, Portugal.
Raquel Pereira
https://orcid.org/0000-0001-6605-8991
Pulmonology Department, Hospital of Braga, Portugal.
João Filipe Cruz
https://orcid.org/0000-0003-3599-8635
Pulmonology Department, Hospital of Braga, Portugal.

Benign metastasizing leiomyoma is a rare disease that primarily affects premenopausal women who have a history of uterine leiomyoma, which is characterized by pulmonary metastases. The pathogenesis of this condition is unknown. Patients are usually asymptomatic or have vague symptoms. Pathological examination in conjunction with immunohistochemistry is required for diagno­sis. Treatment is determined by the patient's age, hormonal status, symptoms, and the extent of the lesions (number, size, and location of nodules), with surgical resection being the most effective. We present the case of a 72-year-old woman who had a total hysterec­tomy 30 years earlier due to myomas and developed a persistent dry cough. Her computed tomography of the chest revealed several small nodules in the pulmonary parenchyma. Because of the nod­ules' small size and difficult accessibility, a surgical biopsy was per­formed for histopathological examination and immunohistochemi­cal staining, which revealed metastasizing leiomyoma. Letrozole treatment was started and was well tolerated.

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How to Cite

Vieira Naia, Joana, Diana Pimenta, Anita Paiva, Rita Costa, Conceição Souto de Moura, Raquel Pereira, and João Filipe Cruz. 2023. “When Benign Leiomyomas Metastasize to the Lungs - a Case Report”. Monaldi Archives for Chest Disease 93 (4). https://doi.org/10.4081/monaldi.2023.2488.
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