Pulmonary embolism and gastric bleed with disseminated mucormycosis - treading dangerous waters

Submitted: August 30, 2022
Accepted: October 28, 2022
Published: November 25, 2022
Abstract Views: 843
PDF: 122
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.


Mucormycosis is an opportunistic infection seen in immunocompromised patients or in surgical and trauma settings with Mucorales wound contamination. In immunocompetent people, disseminated mucormycosis is uncommon. To ensure survival, patients with mucormycosis require early diagnosis and aggressive treatment using a multi-modality approach. We present a case of disseminated mucormycosis in an immunocompetent patient who also had pulmonary embolism and gastrointestinal bleeding. A recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, identified retrospectively by a positive IgM against SARS-CoV-2, was the only risk factor present. This report emphasizes the increased risk of mucormycosis and thromboembolic complications following a recent SARS-CoV-2 infection, as well as its successful treatment with medical therapy alone.



PlumX Metrics


Download data is not yet available.


Spellberg B, Edwards Jr J, Ibrahim A. Novel perspectives on mucormycosis: pathophysiology, presentation, and management. Clin Microbiol Rev 2005;18:556-69. DOI: https://doi.org/10.1128/CMR.18.3.556-569.2005
Roden MM, Zaoutis TE, Buchanan WL, et al. Epidemiology and outcome of zygomycosis: A Review of 929 reported cases. Clin Infect Dis 2005;1:634-53. DOI: https://doi.org/10.1086/432579
Raut A, Huy NT. Rising incidence of mucormycosis in patients with COVID-19: another challenge for India amidst the second wave? Lancet Respir Med 2021;9:e77. DOI: https://doi.org/10.1016/S2213-2600(21)00265-4
Singh AK, Singh R, Joshi SR, Misra A. Mucormycosis in COVID- 19: a systematic review of cases reported worldwide and in India. Diabetes Metab Syndr 2021;15:102146. DOI: https://doi.org/10.1016/j.dsx.2021.05.019
Tan BK, Mainbourg S, Friggeri A, et al. Arterial and venous thromboembolism in COVID-19: a study-level meta-analysis. Thorax 2021;76:970-9. DOI: https://doi.org/10.1136/thoraxjnl-2020-215383
Jacofsky D, Jacofsky EM, Jacofsky M. Understanding antibody testing for COVID-19. J Arthroplasty 2020;35:S74-S81. DOI: https://doi.org/10.1016/j.arth.2020.04.055
Maraví-Poma E, Rodríguez-Tudela JL, de Jalón JG, et al. Outbreak of gastric mucormycosis associated with the use of wooden tongue depressors in critically ill patients. Intensive Care Med 2004;30:724-8. DOI: https://doi.org/10.1007/s00134-003-2132-1
Pak J, Tucci VT, Vincent AL, et al. Mucormycosis in immunochallenged patients. J Emerg Trauma Shock 2008;1:106-13. DOI: https://doi.org/10.4103/0974-2700.42203
Skiada A, Lass-Floerl C, Klimko N, et al. Challenges in the diagnosis and treatment of mucormycosis. Med Mycol 20181;56:93-101. DOI: https://doi.org/10.1093/mmy/myx101
Naqvi HA, Nadeem Yousaf M, Chaudhary FS, Mills L. Gastric mucormycosis: An infection of fungal invasion into the gastric mucosa in immunocompromised patients. Case Rep Gastrointest Med 2020;16:8876125. DOI: https://doi.org/10.1155/2020/8876125
Chikley A, Ben-Ami R, Kontoyiannis DP. Mucormycosis of the central nervous system. J Fungi 2019;8:59. DOI: https://doi.org/10.3390/jof5030059
Mignogna MD, Fortuna G, Leuci S, et al. Mucormycosis in immunocompetent patients: a case-series of patients with maxillary sinus involvement and a critical review of the literature. Int J Infect Dis 2011;15:533-40. DOI: https://doi.org/10.1016/j.ijid.2011.02.005
Nain PS, Matta H, Singh K, et al. Post-operative abdominal wall mucormycosis - a case series. Indian J Surg 2015;77:S253-6. DOI: https://doi.org/10.1007/s12262-012-0786-z

How to Cite

Chauhan, Nishant Kumar, Ashish Agarwal, Naveen Dutt, Taruna Yadav, and Rishabh Kochar. 2022. “Pulmonary Embolism and Gastric Bleed With Disseminated Mucormycosis - Treading Dangerous Waters”. Monaldi Archives for Chest Disease 93 (3). https://doi.org/10.4081/monaldi.2022.2418.