https://doi.org/10.4081/monaldi.2022.2396

Factors affecting the treatment outcome of injection based shorter MDR-TB regimen at a referral centre in India

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Vol. 93 No. 3 (2023)
Submitted: August 5, 2022
Accepted: September 27, 2022
Published: October 5, 2022
Multidrug resistant tuberculosis, MDR-TB shorter regimen, treatment outcome, mortality
Abstract Views: 1846
PDF: 500
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Authors

Kiran B
https://orcid.org/0000-0002-4282-4513
Department of Tuberculosis and Respiratory Diseases, National Institute Tuberculosis and Respiratory Disease, New Delhi, India.
Rupak Singla
drrupaksingla@yahoo.com
https://orcid.org/0000-0003-1806-8831
Department of Tuberculosis and Respiratory Diseases, National Institute Tuberculosis and Respiratory Disease, New Delhi, India.
Neeta Singla
https://orcid.org/0000-0002-1340-3146
Department of Epidemiology and Public Health, National Institute Tuberculosis and Respiratory Disease, New Delhi, India.
Vinay V
https://orcid.org/0000-0003-1691-2111
Department of Tuberculosis and Respiratory Diseases, National Institute Tuberculosis and Respiratory Disease, New Delhi, India.
Kuljeet Singh
https://orcid.org/0000-0002-4160-1465
Department of Tuberculosis and Respiratory Diseases, National Institute Tuberculosis and Respiratory Disease, New Delhi, India.
Madhumita Paul Choudhury
https://orcid.org/0000-0003-2271-9393
Department of Tuberculosis and Respiratory Diseases, National Institute Tuberculosis and Respiratory Disease, New Delhi, India.
Nilotpal Bhattacherjee
https://orcid.org/0000-0001-9342-3093
Department of Tuberculosis and Respiratory Diseases, National Institute Tuberculosis and Respiratory Disease, New Delhi, India.

Rifampicin-resistant/multidrug-resistant tuberculosis (RR/MDR-TB) is a significant burden on global tuberculosis (TB) prevention and eradication efforts. MDR-TB can be treated, but it is expensive, takes a long time (typically two years) and contains potentially toxic drugs. Under certain conditions, the WHO recommends standard regimens lasting 9 to 11 months rather than individual regimens lasting at least 18-20 months. The current study sought to identify factors associated with treatment outcomes in RR/MDR-TB patients receiving an injection-based regimen for 9-11 months. This ambispective (prospective and retrospective) observational study was conducted at a tertiary tuberculosis institute in New Delhi, India. Between February 2021 and March 2022, patients with RR/MDR-pulmonary TB who received an injection-based shorter regimen were enrolled. Factors related to treatment outcomes were investigated and compared in patients who had a successful outcome versus those who did not. A total of 55 patients were enrolled, with 50.91% being successful (cured/treatment completed) and 49.09% failing (including failure, lost to follow up, death, and regimen change). The following factors were significantly associated with the unsuccessful outcome, according to univariate analysis: BMI (<18.5 kg/m2), anaemia, previous anti-TB treatment, bilateral chest X-ray involvement, and far advanced disease on chest X-ray. BMI (<18.5 kg/m2), anaemia, and far advanced disease on chest X-ray were all significantly associated with mortality. Anaemia was associated with an unsuccessful outcome (p=0.049) and mortality (p=0.048) in the multiple logistic regression analysis. Early treatment initiation, improved nutrition and anaemia, and regular monitoring can all improve RR/MDR-TB patients’ outcomes and prognoses.

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How to Cite

B, Kiran, Rupak Singla, Neeta Singla, Vinay V, Kuljeet Singh, Madhumita Paul Choudhury, and Nilotpal Bhattacherjee. 2022. “Factors Affecting the Treatment Outcome of Injection Based Shorter MDR-TB Regimen at a Referral Centre in India”. Monaldi Archives for Chest Disease 93 (3). https://doi.org/10.4081/monaldi.2022.2396.
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