An unexpected diagnosis of a lung mass with endobronchial involvement

Submitted: March 2, 2022
Accepted: April 4, 2022
Published: April 12, 2022
Abstract Views: 764
PDF: 233
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.


Mantle cell lymphoma is a subtype of B-cell non-Hodgkin's lymphoma. Most cases of the disease have extranodal involvement at the time of the initial diagnosis; however, endobronchial involvement is rare. A 51-year-old woman was referred to our hospital because a chest CT showed pathological tissue in the right hilum englobing the pulmonary artery, the left main bronchus and their main lobar branches appearing to be small in caliber, multiple lymphadenopathies up to 4 cm in size in the subcarinal region. A bronchoscopy revealed stenotic lumen with infiltrated hyperemic mucosa of the left upper lobar bronchus and the left lower lobar bronchus. She was diagnosed as having mantle cell lymphoma based on an endobronchial biopsy and transbronchial needle aspiration. The diagnosis was confirmed using immunohistochemical staining.



PlumX Metrics


Download data is not yet available.


Pérez-Galán P, Dreyling M, Wiestner A. Mantle cell lymphoma: biology, pathogenesis, and the molecular basis of treatment in the genomic era. Blood 2011;117:26-38.
Depew ZS, Vassallo R. Pulmonary mantle cell lymphoma: a rare manifestation of an uncommon condition. Rare Tumors 2012;4:e11.
Vose JM. Mantle cell lymphoma: 2015 update on diagnosis, risk-stratification, and clinical management. Am J Hematol 2015;90:739-45.
Armitage JO, Weisenburger DD. New approach to classifying non-Hodgkin's lymphomas: clinical features of the major histologic subtypes. Non-Hodgkin's Lymphoma Classification Project. J Clin Oncol 1998;16:2780-95.
Banerji A, Sheffer AL. The spectrum of chronic angioedema. Allergy Asthma Proc 2009;30:11-6.
Castelli R, Deliliers DL, Zingale LC et al. Lymphoproliferative disease and acquired C1 inhibitor deficiency. Haematologica 2007;92:716-8.
Foti R, Fazio P, Lizzio G, et al. Angioedema: first manifestation of non-Hodgkin’s lymphoma Ann Ital Med Int 2002;17:185.
Rose RM, Grigas D, Strattemeir E, et al. Endobronchial involvement with non-Hodgkin's lymphoma. A clinical-radiologic analysis. Cancer 1987;57:1750-5.
Solomonov A, Zuckerman T, Goralnik L, et al. Non-Hodgkin's lymphoma presenting as an endobronchial tumor: report of eight cases and literature review. Am J Hematol 2008;83:416-9.
McRae M, Wong Cs, Jeffery GM. Endobronchial non-Hodgkin's lymphoma. Respir Med 1998;92:975-7.
Kilgore TL, Chasen MH. Endobronchial non-Hodgkin's lymphoma. Chest 1983;84:58-61.
Katono K, Shirasawa M, Harada S, et al. Endobronchial involvement of mantle cell lymphoma: A case report. Respir Med Case Rep 2016;19:77-9.
Tong L, Gan G, Xu C, et al. Tracheobronchial involvement of mantle cell lymphoma. Respirol Case Rep 2018;6:e00346.

How to Cite

Köhl, Johanna, Floriana Bardaro, and Emanuele Stirpe. 2022. “An Unexpected Diagnosis of a Lung Mass With Endobronchial Involvement”. Monaldi Archives for Chest Disease 92 (4).