Management of bronchial asthma in 2021

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Submitted: November 8, 2021
Accepted: January 30, 2022
Published: February 22, 2022
Abstract Views: 1105
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To The Editor,

The Global Initiative for Asthma (GINA) 2021 update was published on the 28th of April, 2021. There are significant changes, including treatment of mild asthma, the role of azithromycin, treatment of asthma in COVID-19 times, and role of biologics...



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Global Initiative for Asthma. Global strategy for asthma management and prevention (updated 2021). Accessed on: 8 Nov 2021. Available from:
Ish P, Malhotra N, Gupta N. GINA 2020: what's new and why? J Asthma 2021;58:1273-7. DOI:
O’Byrne PM, FitzGerald JM, Bateman ED, et al. Inhaled combined budesonide- formoterol as needed in mild asthma. N Engl J Med. 2018;378:1865-76. DOI:
Bateman ED, Reddel HK, O’Byrne PM, et al. As-needed budesonide- formoterol versus maintenance budesonide in mild asthma. N Engl J Med 2018;378:1877-87. DOI:
Beasley R, Holliday M, Reddel HK, et al. Controlled trial of budesonide formoterol as needed for mild asthma. N Engl J Med 2019;380:2020-30. DOI:
Hardy J, Baggott C, Fingleton J, et al. Budesonide-formoterol reliever therapy versus maintenance budesonide plus terbutaline reliever therapy in adults with mild to moderate asthma (PRACTICAL): a 52-week, openlabel, multicentre, superiority, randomised controlled trial. Lancet 2019;394:919-98. DOI:
Nwaru BI, Ekström M, Hasvold P, et al. Overuse of short-acting β2-agonists in asthma is associated with increased risk of exacerbation and mortality: a nationwide cohort study of the global SABINA programme. Eur Respir J 2020;55:1901872. DOI:
Virchow JC, Kuna P, Paggiaro P, et al. Single inhaler extrafine triple therapy in uncontrolled asthma (TRIMARAN and TRIGGER): two double-blind, parallel-group, randomised, controlled phase 3 trials. Lancet 2019;394:1737-49. DOI:
Lee LA, Bailes Z, Barnes N, et al. Efficacy and safety of once-daily single-inhaler triple therapy (FF/UMEC/VI) versus FF/VI in patients with inadequately controlled asthma (CAPTAIN): a double-blind, randomised, phase 3A trial. Lancet Respir Med 2021;9:69-84. DOI:
Lugogo NL, Kreindler JL, Martin UJ, et al. Blood eosinophil count group shifts and kinetics in severe eosinophilic asthma. Ann Allergy Asthma Immunol 2020;125:171-6. DOI:
Humbert M, Taille C, Mala L, et al. Omalizumab effectiveness in patients with severe allergic asthma according to blood eosinophil count: the STELLAIR study. Eur Respir J 2018;51:1702523. DOI:
Hiles SA, McDonald VM, Guilhermino M, et al. Does maintenance azithromycin reduce asthma exacerbations? An individual participant data meta-analysis. Eur Respir J 2019;54:1901381. DOI:
Lazarinis N, Jørgensen L, Ekström T, et al. Combination of budesonide/formoterol on demand improves asthma control by reducing exercise-induced bronchoconstriction. Thorax 2014;69:130-6. DOI:
14. O'Byrne PM, FitzGerald JM, Bateman ED, et al. Effect of a single day of increased as-needed budesonide-formoterol use on short-term risk of severe exacerbations in patients with mild asthma: a post-hoc analysis of the SYGMA 1 study. Lancet Respir Med 2021;9:149-58. DOI:
Sobieraj DM, Weeda ER, Nguyen E, et al. Association of inhaled corticosteroids and long-acting β-agonists as controller and quick relief therapy with exacerbations and symptom control in persistent asthma: A systematic review and meta-analysis. JAMA 2018;319:1485-96. DOI:
Williamson EJ, Walker AJ, Bhaskaran K, et al. Factors associated with COVID-19-related death using OpenSAFELY. Nature 2020;584:430-6. DOI:
Liu S, Cao Y, Du T, Zhi Y. Prevalence of comorbid asthma and related outcomes in COVID-19: a systematic review and meta-analysis. J Allergy Clin Immunol Pract 2021;9:693-701. DOI:

How to Cite

Gupta, Nitesh, Nipun Malhotra, Shekhar Kunal, and Pranav Ish. 2022. “Management of Bronchial Asthma in 2021”. Monaldi Archives for Chest Disease 92 (4).