Cardiology - Case Reports Open access

Left atrial invasion of a lung cancer: a case report

Authors

Published
3 December 2021
Section
Cardiology - Case Reports

Abstract

Lung cancer is the leading neoplastic form worldwide for both incidence and mortality and represents the largest contributor to new cancer diagnosis. Cardiac extensions of a pulmonary neoplasm are rare and dramatically under-diagnosed because of the extreme variability of clinical presentation and frequently are expression of an advanced-stage primary lung cancer. The invasion often happens through pulmonary veins in absence of a clear respiratory impairment. Symptoms related to the cardiac involvement as the first presentation of a malignant pulmonary neoplasm are very uncommon and related with poor outcome. Here we present a case of invasion of the left atrium of a pulmonary neoplasm with initial cardiac manifestations and a laboratory finding of hypercalcemia.

References

  1. Lin MT, Ku SC, Wu MZ, Yu CJ. Intracardiac extension of lung cancer via the pulmonary vein. Thorax 2008;63:1122. DOI: https://doi.org/10.1136/thx.2007.090373
  2. Weinberg BA, Conces DJ Jr, Waller BF. Cardiac manifestations of noncardiac tumors. Part I: Direct effects. Clin Cardiol 1989;12:289-96. DOI: https://doi.org/10.1002/clc.4960120512
  3. Stewart AF. Clinical practice. Hypercalcemia associated with cancer. N Engl J Med 2005;352:373-9 DOI: https://doi.org/10.1056/NEJMcp042806
  4. Otero J, Lenihan DJ. The "normothermic" Osborn wave induced by severe hypercalcemia. Tex Heart Inst J 2000;27:316-7.
  5. Cipriano F, Dessoti LU, Rodrigues AJ, et al. Report of a lung carcinoma extended to the left atrium through pulmonary vein. J Thorac Dis 2018;10:E46-E51. DOI: https://doi.org/10.21037/jtd.2017.12.33
  6. Watanabe N, Kubo K. Images in cardiology: Intra-left atrial invasive mass extended via the pulmonary vein. Heart 2001;85:271. DOI: https://doi.org/10.1136/heart.85.3.271
  7. Ballo P, Laureano R, Briganti M, et al. Left atrial mass invasion from pulmonary neoplasm extension via the right upper pulmonary vein presenting as ipsilateral stroke. Case Rep Med 2016;2016:7084234. DOI: https://doi.org/10.1155/2016/7084234
  8. Brandt RR, Rubin J, Reeder GS. Intracardiac extension of a lung tumor causing left ventricular inflow obstruction. J Am Soc Echocardiogr 1995;8:930-3. DOI: https://doi.org/10.1016/S0894-7317(05)80019-7
  9. Chandra R, Abugroun A, Goldberg A, et al. Small cell lung cancer invading the left atrium with subsequent malignant embolic stroke: A case report and review of literature. Cardiol Res 2019;10:188-92. DOI: https://doi.org/10.14740/cr752w
  10. Hamilton F, Carroll R, Hamilton W, Salisbury C. The risk of cancer in primary care patients with hypercalcaemia: a cohort study using electronic records. Br J Cancer 2014;111:1410-2. DOI: https://doi.org/10.1038/bjc.2014.433
  11. Edwards CM, Johnson RW. From good to bad: The opposing effects of PTHrP on tumor growth, dormancy, and metastasis throughout cancer progression. Front Oncol 2021;11:644303. DOI: https://doi.org/10.3389/fonc.2021.644303
  12. Mirrakhimov AE. Hypercalcemia of malignancy: An update on pathogenesis and management. N Am J Med Sci 2015;7:483-93. DOI: https://doi.org/10.4103/1947-2714.170600
  13. Htwe KK, Aung TT. Diagnostic challenges of a mass in the left atrium. Cureus 2020;12:e8620. DOI: https://doi.org/10.7759/cureus.8620

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