Paradoxical role of oxygen in the treatment of patients with COVID-19

Submitted: May 6, 2021
Accepted: August 9, 2021
Published: September 15, 2021
Abstract Views: 982
PDF: 380
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Dear Editor,
Coronavirus disease-2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) was declared a pandemic by WHO on 11 March 2020 and has adversely affected human society and disrupted global health...



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Mahalmani VM, Mahendru D, Semwal A, et al. COVID-19 pandemic: A review based on current evidence. Indian J Pharmacol 2020;52:117-129. DOI:
Li H, Liu S-M, Yu X-H, et al. Coronavirus disease 2019 (COVID-19): current status and future perspectives. Int J Antimicrob Agents 2020;55:105951. DOI:
Hartenian E, Nandakumar D, Lari A, et al. The molecular virology of coronaviruses. J Biol Chem 2020 Sep 11;295:12910–34. DOI:
Hanidziar D, Robson SC. Hyperoxia and modulation of pulmonary vascular and immune responses in COVID-19. Am J Physiol Lung Cell Mol Physiol 2021;320:L12-6. DOI:
Matthay MA, Zemans RL. The acute respiratory distress syndrome: pathogenesis and treatment. Annu Rev Pathol 2011;6:147-63. DOI:
Ohshimo S. Oxygen administration for patients with ARDS. J Intensive Care 2021;9:17. DOI:
Mach WJ, Thimmesch AR, Pierce JT, Pierce JD. Consequences of hyperoxia and the toxicity of oxygen in the lung. Nurs Res Pract 2011;2011:260482. DOI:
Pagano A, Barazzone-Argiroffo C. Alveolar cell death in hyperoxia-induced lung injury. Ann N Y Acad Sci 2003;1010:405-16. DOI:
Budinger GRS, Mutlu GM. Balancing the risks and benefits of oxygen therapy in critically III adults. Chest 2013;143:1151–62. DOI:
Myti D, Gunjak M, Casado F, et al. Elevated FiO2 increases SARS-CoV-2 co-receptor expression in respiratory tract epithelium. Am J Physiol Lung Cell Mol Physiol 2020;319:L670–4. DOI:
Kim V, Benditt JO, Wise RA, Sharafkhaneh A. Oxygen therapy in chronic obstructive pulmonary disease. Proc Am Thorac Soc 2008;5:513–8. DOI:
Ergan B, Nava S. Long-term oxygen therapy in COPD patients who do not meet the actual recommendations. COPD 2017;14:351–66. DOI:
Hedenstierna G, Rothen HU. Atelectasis formation during anesthesia: causes and measures to prevent it. J Clin Monit Comput 2000;16:329-35. DOI:
Saugstad OD. Oxygenation of the immature infant: A commentary and recommendations for oxygen saturation targets and alarm limits. Neonatology 2018;114:69–75. DOI:
La Fauci V, Costa GB, Facciolà A, et al. Humidifiers for oxygen therapy: what risk for reusable and disposable devices? J Prev Med Hyg 2017;58:E161–5.
Koch A, Kähler W, Klapa S, et al. The conundrum of using hyperoxia in COVID-19 treatment strategies: may intermittent therapeutic hyperoxia play a helpful role in the expression of the surface receptors ACE2 and Furin in lung tissue via triggering of HIF-1α? Intensive Care Med Exp 2020;8:53. DOI:
Crimi C, Noto A, Cortegiani A, et al. Noninvasive respiratory support in acute hypoxemic respiratory failure associated with COVID-19 and other viral infections. Minerva Anestesiol 2020;86:1190-204. DOI:

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How to Cite

Maharana , Biswajit, Pallab Chakraborty, Sudhan Rackimuthu, Rusab Baig, and Shreeji Kadakia. 2021. “Paradoxical Role of Oxygen in the Treatment of Patients With COVID-19”. Monaldi Archives for Chest Disease 92 (2).