IL1RL1 single nucleotide polymorphisms are associated with asthma in the Iranian population

Interleukin 1 receptor, type I (IL1R1)
Submitted: November 24, 2020
Accepted: December 20, 2021
Published: December 28, 2021
Abstract Views: 2095
PDF: 404
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Asthma is a chronic and multifactorial disease which is known to result from environmental and genetic factors. Interleukin 1 receptor-like 1 (IL1RL1) is a receptor, which promotes inflammatory responses after binding to its ligand IL-33. Several studies have shown that IL1RL1 gene polymorphisms are related to susceptibility or protection to asthma. The objective of this study was to evaluate the association between two IL1RL1 single nucleotide polymorphisms (rs10208293 and rs1041973) and the risk of asthma in the Iranian population. We performed genotyping of the IL1RL1 SNPs in 126 adult asthmatics and 300 healthy controls using TaqMan genotyping assay. Moreover, total serum IgE level, eosinophil count, and skin prick test were accomplished. The results indicated that the AA genotype of rs10208293 was positively associated with asthma susceptibility (p=0.028). We did not find any association between rs1041973 and asthma. Overall, our findings indicate that rs10208293 has a positive association with asthma in the Iranian population.

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Morteza Fallahpour, Department of Allergy, Rasool-e-Akram Hospital, Iran University of Medical Sciences, Tehran

Firoozabadi Hospital, Iran University of Medical Sciences, Tehran

Mohammad-Ali Assarehzadegan, Department of Immunology, School of Medicine, Iran University of Medical Science, Tehran

Immunology Research Center, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran

How to Cite

Ranjbar, Maral, Mojdeh Matloubi, Shaghayegh Sadegh, Morteza Fallahpour, Leila Janani, and Mohammad-Ali Assarehzadegan. 2021. “IL1RL1 Single Nucleotide Polymorphisms Are Associated With Asthma in the Iranian Population”. Monaldi Archives for Chest Disease 92 (3). https://doi.org/10.4081/monaldi.2021.1697.