Metastatic mandibular ameloblastoma of the lung ten years after primary resection: A rare case report

Submitted: October 17, 2020
Accepted: January 31, 2021
Published: April 9, 2021
Abstract Views: 1308
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Authors

Ameloblastoma is a rare odontogenic neoplasm of the jaw. It usually behaves as a benign, slow growing tumour of the oral cavity with a high recurrence rate, especially when it is inadequately resected. A small proportion of ameloblastomas metastasize to distant organs, with lungs representing the most common site of metastatic spread. In this report, we present the case of a middle-aged man with two pulmonary nodules and a history of mandibular ameloblastoma excised 10 years prior to this radiological finding. Following resection and histopathological analysis of the lung lesion, a diagnosis of metastatic ameloblastoma was confirmed. No local recurrence of the primary tumour was identified. At 1-year follow-up, the patient had no evidence of local or metastatic disease.

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Citations

Oomens MA, Van der Waal I. Epidemiology of ameloblastomas of the jaws; a report from the Netherlands. Med Oral Patol Oral Cir Bucal 2014;19:e581-3. DOI: https://doi.org/10.4317/medoral.20316
MacDonald-Jankowski DS, Yeung R, Lee KM, Li TK. Ameloblastoma in the Hong Kong Chinese. Part 2: systematic review and radiological presentation. Dentomaxillofac Radiol 2004;33:141-51. DOI: https://doi.org/10.1259/dmfr/28001874
Nagi R, Sahu S, Rakesh N. Molecular and genetic aspects in the etiopathogenesis of ameloblastoma: An update. J Oral Maxillofac Pathol 2016;20:497-504. DOI: https://doi.org/10.4103/0973-029X.190954
Verneuil A, Sapp P, Huang C, Abemayor E. Malignant ameloblastoma: classification, diagnostic, and therapeutic challenges. Am J Otolaryngol 2002;23:44-8. DOI: https://doi.org/10.1053/ajot.2002.28769
Thompson L. World Health Organization classification of tumours: pathology and genetics of head and neck tumours. Ear Nose Throat J 2006;85:74. DOI: https://doi.org/10.1177/014556130608500201
Van Dam SD, Unni KK, Keller EE. Metastasizing (malignant) ameloblastoma: review of a unique histopathologic entity and report of Mayo Clinic experience. J Oral Maxillofac Surg 2010;68:2962-74. DOI: https://doi.org/10.1016/j.joms.2010.05.084
Laughlin EH. Metastasizing ameloblastoma. Cancer 1989;64:776-80. DOI: https://doi.org/10.1002/1097-0142(19890801)64:3<776::AID-CNCR2820640335>3.0.CO;2-8
Jayaraj G, Sherlin HJ, Ramani P, et al. Metastasizing Ameloblastoma - a perennial pathological enigma? Report of a case and review of literature. J Craniomaxillofac Surg 2014;42:772-9. DOI: https://doi.org/10.1016/j.jcms.2013.11.009
White RM, Patterson JW. Distant skin metastases in a long-term survivor of malignant ameloblastoma. J Cutan Pathol 1986;13:383-9. DOI: https://doi.org/10.1111/j.1600-0560.1986.tb00474.x
Hayakawa K, Hayashi E, Aoyagi T, et al. Metastatic malignant ameloblastoma of the kidneys. Int J Urol 2004;11:424-6. DOI: https://doi.org/10.1111/j.1442-2042.2004.00822.x
Nguyen BD. Malignant ameloblastoma with thoracic vertebral metastasis: PET/CT and MR imaging. Clin Nucl Med 2005;60:450-2. DOI: https://doi.org/10.1097/01.rlu.0000163382.16320.6b
Azumi T, Nakajima T, Takeuchi S, et al. Malignant ameloblastoma with metastasis to the skull: report of case. J Oral Surg 1981;39:690-6.
Vorzimer J, Perla D. An Instance of adamantinoma of the Jaw with Metastases to the Right Lung. Am J Pathol 1932;8:445-54.
Rizzitelli A, Smoll NR, Chae MP, et al. Incidence and overall survival of malignant ameloblastoma. PLoS One 2015;10:e0117789. DOI: https://doi.org/10.1371/journal.pone.0117789
Berger AJ, Son J, Desai NK. Malignant ameloblastoma: concurrent presentation of primary and distant disease and review of the literature. J Oral Maxillofac Surg 2012;70:2316-26. DOI: https://doi.org/10.1016/j.joms.2011.11.004
Grünwald V, Le Blanc S, Karstens JH, et al. Metastatic malignant ameloblastoma responding to chemotherapy with paclitaxel and carboplatin. Ann Oncol 2001;12:1489-91. DOI: https://doi.org/10.1023/A:1012522929861
Lanham RJ. Chemotherapy of metastatic ameloblastoma. A case report and review of the literature. Oncology 1987;44:133-4. DOI: https://doi.org/10.1159/000226461
González-González R, López-Verdín S, Lavalle-Carrasco J, et al. Current concepts in ameloblastoma-targeted therapies in B-raf proto-oncogene serine/threonine kinase V600E mutation: Systematic review. World J Clin Oncol 2020;11:31-42. DOI: https://doi.org/10.5306/wjco.v11.i1.31
Broudic-Guibert M, Blay JY, Vazquez L, et al. Persistent response to vemurafenib in metastatic ameloblastoma with BRAF mutation: a case report. J Med Case Rep 2019;13:245. DOI: https://doi.org/10.1186/s13256-019-2140-6
Hasim FW, Poon CC, Smith AC. Prolonged survival with confirmed metastatic pulmonary ameloblastoma. Int J Oral Maxillofac Surg 2007;36:953-5. DOI: https://doi.org/10.1016/j.ijom.2007.02.010

How to Cite

Kapriniotis, Konstantinos, Angelina Bania, Savvas Lampridis, Georgios Geropoulos, Sofoklis Mitsos, Fleur Monk, David A. Moore, and Nikolaos Panagiotopoulos. 2021. “Metastatic Mandibular Ameloblastoma of the Lung Ten Years After Primary Resection: A Rare Case Report”. Monaldi Archives for Chest Disease 91 (2). https://doi.org/10.4081/monaldi.2021.1643.