Endothelial dysfunction in type 2 diabetic patients with normal coronary arteries. A peripheral arterial tonometry study

Submitted: December 3, 2015
Accepted: December 3, 2015
Published: December 3, 2015
Abstract Views: 1131
PDF: 510
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Aim: to evaluate endothelial function (EF) in diabetic and non-diabetic patients without CAD by peripheral artery tonometry (PAT) technique. Methods: a cohort of 94 patients (55 men and 39 postmenopausal women; mean age 63±9 years) undergoing coronary angiography was divided into 2 groups: 58 patients with DM and (group 1) and 36 patients without DM. Endothelial dysfunction (ED) was assessed by digital pulse amplitude, using a fingertip peripheral arterial tonometry (PAT). As a measure of ED, reactive hyperemia index (RHI) was calculated as the ratio of the digital pulse volume during reactive hyperemia following 5 min ischemia and its basal value. Results: prevalence of cardiovascular risk factors was similar between the two groups. RHI values were significantly lower in diabetic patients compared to non-diabetics (1.72±0.34 vs 2.00±0.44; p<0.005) and they correlated with levels of glycosylated hemoglobin (p=0.05; r=-0.266). Conclusion: despite similar level of other risk factors, EF was much more impaired in diabetic patients than in non-diabetics. These evidences further support the impact of DM on cardiovascular risk.



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Ruggiero, Donatella, Gianluigi Savarese, Roberto Formisano, Ada Bologna, Giacomo Mattiello, Elisabetta Pirozzi, Francesco Gambardella, Francesco Lo Iudice, Laura Petraglia, Alice Vitagliano, Laura Casaretti, Giuseppe Luca Della Ratta, Susanna Mosca, and Pasquale Perrone Filardi. 2015. “Endothelial Dysfunction in Type 2 Diabetic Patients With Normal Coronary Arteries. A Peripheral Arterial Tonometry Study”. Monaldi Archives for Chest Disease 78 (1). https://doi.org/10.4081/monaldi.2012.142.