A case of bleomycin-induced lung toxicity

https://doi.org/10.4081/monaldi.2018.981

Authors

  • Cuneyt Tetikkurt | tetikkurt@gmail.com Istanbul University, Cerrahpasa Medical Faculty, Pulmonary Diseases Department, Turkey. http://orcid.org/0000-0002-4122-2908
  • Deniz Ongel Istanbul University, Cerrahpasa Medical Faculty, Pulmonary Diseases Department, Turkey.
  • Seza Tetikkurt University of Health Sciences, BaÄŸcılar Training and Research Hospital, Department of Pathology, Turkey.

Abstract

A 64-year-old female was admitted for dry cough, dyspnea, fever, loss of appetite, and weight loss. Past medical history revealed scoliosis, cholecystectomy, and Hodgkin lymphoma. ABG values were: pH: 7.42, pCO2: 40.2 mm Hg, pO2: 61.4 mm Hg. Chest CT showed cystic lesions, emphysema, ground glass, and reticular opacities. ABG values worsened under 8L/min nasal oxygen. The patient underwent bilevel positive airway pressure (BiPAP) and methylprednisolone 60 mg/day bid was commenced. The final diagnosis was respiratory insufficiency due to bleomycin toxicity. The patient deceased on the sixth day after transfer to the intensive care unit. Bleomycin is an effective chemotherapeutic agent used for Hodgkin lymphoma treatment. It causes significant lung toxicity in half of the patients. Clinicians should always remember that bleomycin toxicity may lead to fatal complications in patients with comorbid conditions. We present this case to remark the possible consequences of bleomycin toxicity and the precautions taken to preclude bleomycin-induced pulmonary complications are discussed.

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Published
2018-11-06
Info
Issue
Section
Pneumology - Case Reports
Keywords:
Bleomycin, bleomycin-induced lung toxicity, pulmonary fibrosis, bleomycin toxicity.
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  • PDF: 621
How to Cite
Tetikkurt, Cuneyt, Deniz Ongel, and Seza Tetikkurt. 2018. “A Case of Bleomycin-Induced Lung Toxicity”. Monaldi Archives for Chest Disease 88 (3). https://doi.org/10.4081/monaldi.2018.981.

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