Nonsteroid anti-inflammatory drugs (NSAID) and risk of cardiovascular events. Literature review and clinical implications


  • Pier Luigi Temporelli | Divisione di Cardiologia Riabilitativa, Fondazione Salvatore Maugeri, IRCCS, Istituto Scientifico di Veruno, Italy.
  • Giovanni Battista Zito Ambulatorio di Cardiologia ASL Napoli 3 Sud - Pompei, Italy.
  • Roberto Franco Pedretti UO di Cardiologia Riabilitativa, Fondazione Salvatore Maugeri, IRCCS, Istituto Scientifico di Tradate, Italy.
  • Francesco Iachini Belisarii Ambulatorio di Cardiologia AUSL di Pescara, Italy.
  • Giuseppe Putortì Ambulatorio di Cardiologia ASP Reggio Calabria, Italy.
  • Pompilio Faggiano UO Cardiologia, Spedali Civili di Brescia, Italy.


Non steroid anti-inflammatory drugs (NSAIDs) are largely used for treatment of acute and chronic pain, even for long periods of time (months or years). While it is known that their use is frequently associated with gastrointestinal damage, including major bleedings from peptic ulcer, the risk of cardiovascular events related to NSAID has received much less attention. However, there is a large body of evidence showing that NSAIDs (both “traditionalâ€, such as diclofenac or indobufen, and selective cyclooxygenase inhibitors, COX-2) are associated with a significant increase of risk of cardiovascular events, both fatal and nonfatal. Consequently, several options have been proposed for the treatment of pain, including the use of analgesic drugs with different mechanisms of action, such as the opiates. Of interest, the Italian Drug Agency (AIFA) published a few years ago a warning (Nota 66) on the careful prescription of NSAIDs in patients with overt heart disease, such as coronary artery disease and heart failure. Aim of this paper is to present the current status of knowledge on the proper use of NSAIDs and other analgesic drugs in the management of acute and chronic pain.



PlumX Metrics


Download data is not yet available.


non steroid anti-inflammatory drugs, opiates, acute pain, chronic pain
  • Abstract views: 2066

  • PDF: 1365
How to Cite
Temporelli, Pier Luigi, Giovanni Battista Zito, Roberto Franco Pedretti, Francesco Iachini Belisarii, Giuseppe Putortì, and Pompilio Faggiano. 2015. “Nonsteroid Anti-Inflammatory Drugs (NSAID) and Risk of Cardiovascular Events. Literature Review and Clinical Implications”. Monaldi Archives for Chest Disease 82 (3).

Most read articles by the same author(s)

1 2 3 4 5 > >>