Hyperimmune plasma infusion in an immunocompromised Covid-19 patient previously treated for follicular lymphoma



  • Guido Levi | guido.levi@yahoo.it Interventional Pulmonology Department, ASST Spedali Civili, Brescia, Italy. https://orcid.org/0000-0002-7163-2270
  • Chiara Rocchetti Interventional Pulmonology Department, ASST Spedali Civili, Brescia, Italy.
  • Roberto Magri Interventional Pulmonology Department, ASST Spedali Civili, Brescia, Italy. https://orcid.org/0000-0003-1667-2277
  • Silvia Uccelli Interventional Pulmonology Department, ASST Spedali Civili, Brescia, Italy.
  • Damiano Bottone Interventional Pulmonology Department, ASST Spedali Civili, Brescia, Italy.
  • Federico Quadri Interventional Pulmonology Department, ASST Spedali Civili, Brescia, Italy.
  • Mauro Novali Interventional Pulmonology Department, ASST Spedali Civili, Brescia, Italy.
  • Alessandro D. Santin Department of Obstetrics & Gynecology, Yale University School of Medicine, New Haven, CT, United States.
  • Michela Bezzi Interventional Pulmonology Department, ASST Spedali Civili, Brescia, Italy.


Covid-19 in immunocompromised patients shows a prolonged course and may lead to a poor prognosis. Although data on hyperimmune plasma for treatment of Covid-19 suggest an improved outcome in immunocompetent patients, limited data are currently available in immunocompromised patients. We present the case of a 62-year-old Caucasian woman, who was previously treated with obinutuzumab and bendamustine for follicular lymphoma and showed a prolonged positive test for Covid-19. Since no improvement was observed with standard of care (including remdesivir), the possibility of hyperimmune plasma infusion was discussed. A first dose of hyperimmune plasma was administered, with subsequent onset of fever, increasing inflammatory indexes and worsening radiological findings. Three days later a second dose of plasma was administered. Within twelve hours cough and fever disappeared, and oxygen at rest was discontinued. The patient was discharged 5 days later, and nasopharyngeal swabs resulted negative 16 days after discharge.



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COVID-19 - Collection of articles on the Coronavirus outbreak
Supporting Agencies
Covid-19, hyperimmune plasma, case report, lymphoma, cancer
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How to Cite
Levi, Guido, Chiara Rocchetti, Roberto Magri, Silvia Uccelli, Damiano Bottone, Federico Quadri, Mauro Novali, Alessandro D. Santin, and Michela Bezzi. 2021. “Hyperimmune Plasma Infusion in an Immunocompromised Covid-19 Patient Previously Treated for Follicular Lymphoma”. Monaldi Archives for Chest Disease, June. https://doi.org/10.4081/monaldi.2021.1867.

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