Takotsubo syndrome in association with pheochromocytoma: clinical and practical considerations



  • Kenan Yalta | kyalta@gmail.com Cardiology Department, Trakya University, Edirne, Turkey.
  • Ugur Ozkan Cardiology Department, Trakya University, Edirne, Turkey.
  • Tulin Yalta Pathology Department, Trakya University, Edirne, Turkey.
  • Ertan Yetkin Cardiology Department, Derindere Hospital, Istanbul, Turkey.


In clinical practice, pathophysiology of Takotsubo syndrome (TTS) has been attributed to adrenergic discharge mostly associated with a variety of stressors. Occasionally, organic sources of adrenergic discharge (including pheochromocytoma) might also account for this phenomenon and are not considered as exclusion criteria for the diagnosis of TTS (as opposed to previous suggestions). We read with great interest the recently published article by Maffè et al. that describes a case of fatal TTS due to a ruptured pheochromocytoma in a middle-aged male. In this context, we would like to comment on this interesting case and potential implications of TTS associated with pheochromocytoma....



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Maffè S, Dellavesa P, Paffoni P, et al. Takotsubo syndrome and pheochromocytoma: an insidious combination. Monaldi Arch Chest Dis 2021. doi: 10.4081/monaldi.2021.1711. Epub ahead of print. DOI: https://doi.org/10.4081/monaldi.2021.1711

Yalta K, Yetkin E, Yalta T. Systemic inflammation in patients with Takotsubo syndrome: a review of mechanistic and clinical implications. Monaldi Arch Chest Dis 2021;91:1718. DOI: https://doi.org/10.4081/monaldi.2021.1718

Yalta K, Taylan G, Yalta T, et al. Takotsubo cardiomyopathy in the setting of multiple sclerosis: a multifaceted phenomenon with important implications. Monaldi Arch Chest Dis 2020;90:1420. DOI: https://doi.org/10.4081/monaldi.2020.1420

Y-Hassan S. Clinical features and outcome of pheochromocytoma-induced takotsubo syndrome: Analysis of 80 published cases. Am J Cardiol 2016;117:836-44. DOI: https://doi.org/10.1016/j.amjcard.2016.03.019


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takotsubo syndrome, pheochromocytoma, potential implications
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How to Cite
Yalta, Kenan, Ugur Ozkan, Tulin Yalta, and Ertan Yetkin. 2021. “Takotsubo Syndrome in Association With Pheochromocytoma: Clinical and Practical Considerations”. Monaldi Archives for Chest Disease, May. https://doi.org/10.4081/monaldi.2021.1848.