A young lady with dyspnoea: Quest for the cause
Pulmonary hypertension (PH) is a common cause of dyspnoea. The management and prognosis of PH varies with the underlying aetiology. Hence the detection of the cause of PH is important. Obliterative bronchiolitis (OB) is a common but under-recognised cause of PH. OB is usually secondary to childhood infections known as post-infectious OB. It can also be secondary to other diseases, but cryptogenic OB is an extremely rare entity. Here we share a unique case of PH due to cryptogenic OB and its successful outcome with optimal management.
Galiè N, Humbert M, Vachiery JL, et al. ESC Scientific Document Group, 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS). Eur Heart J 2016;37:67-119. DOI: https://doi.org/10.1093/eurheartj/ehv317
Simonneau G, Montani D, Celermajer DS, et al. Haemodynamic definitions and updated clinical classification of pulmonary hypertension. Eur Respir J 2019;53:1801913. DOI: https://doi.org/10.1183/13993003.01913-2018
Burgel PR, Bergeron A, de Blic J, et al. Small airways diseases, excluding asthma and COPD: an overview. Eur Respir Rev 2013;22:131–47. DOI: https://doi.org/10.1183/09059180.00001313
Hansell DM. Small airways disease: Detection and insights with computed tomography. Eur Respir J 2001;17:1294-313. DOI: https://doi.org/10.1183/09031936.01.00206101
Raju S, Ghosh S, Mehta AC. Chest CT signs in pulmonary disease. A pictorial review. Chest 2017;151:1356-74. DOI: https://doi.org/10.1016/j.chest.2016.12.033
Kligerman SJ, Henry T, Lin CT, et al. Mosaic attenuation: Etiology, methods of differentiation, and pitfalls. Radiographics 2015 35:1360-80. DOI: https://doi.org/10.1148/rg.2015140308
Lewis G, Hoey ETD, Reynolds JH, et al. Multi-detector CT assessment in pulmonary hypertension: techniques, systematic approach to interpretation and key findings. Quant Imaging Med Surg 2015;5:423-32.
Epler GR. Diagnosis and treatment of constrictive bronchiolitis. F1000 Med Rep 2010;2:32. DOI: https://doi.org/10.3410/M2-32
Markopoulou KD, Cool CD, Elliot TL, et al. Obliterative bronchiolitis: varying presentations and clinicopathological correlation. Eur Respir J 2002;19:20-30. DOI: https://doi.org/10.1183/09031936.02.00282001
Joshi JM, Gothi D. Post infectious obliterative bronchiolitis. Lung India 2006;23:75-7. DOI: https://doi.org/10.4103/0970-2113.44413
Epler GR. Constrictive bronchiolitis obliterans: the fibrotic airway disorder. Expert Rev Resp Med 2007;1:139-47. DOI: https://doi.org/10.1586/17476318.104.22.168
Turton CW, Williams G, Green M. Cryptogenic obliterative bronchiolitis in adults. Thorax 1981;36:805-10. DOI: https://doi.org/10.1136/thx.36.11.805
Kraft M, Mortenson RL, Colby TV, et al. Cryptogenic constrictive bronchiolitis. A clinicopathologic study. Am Rev Respir Dis 1993;148:1093-101. DOI: https://doi.org/10.1164/ajrccm/148.4_Pt_1.1093
Callahan SJ, Vranic A, Flors L, et al. Sporadic obliterative bronchiolitis: Case series and systematic review of the literature. Mayo Clin Proc Innov Qual Outcomes 2019 1;3:86-93. DOI: https://doi.org/10.1016/j.mayocpiqo.2018.10.003
Jerkic SP, Brinkmann F, Calder A, et al. Postinfectious bronchiolitis obliterans in children: Diagnostic workup and therapeutic options: A workshop report. Can Respir J 2020;2020:5852827. DOI: https://doi.org/10.1155/2020/5852827
- Abstract views: 136
- PDF: 45
Copyright (c) 2021 The Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.