Spontaneous pneumomediastinum in COVID-19 pneumonia



  • Marco Loffi Division of Cardiology, Cremona Hospital, Italy.
  • Valentina Regazzoni | valentina15686@hotmail.it Division of Cardiology, Cremona Hospital, Italy. https://orcid.org/0000-0001-6758-2410
  • Pietro Sergio Division of Radiology, Cremona Hospital, Italy. https://orcid.org/0000-0002-5714-6401
  • Enrico Martinelli Division of Pneumology, Cremona Hospital, Italy. https://orcid.org/0000-0001-8390-0714
  • Italo Stifani Division of Pneumology, Cremona Hospital, Italy. https://orcid.org/0000-0002-7876-8808
  • Filippo Quinzani Division of Cardiology, Cremona Hospital, Italy.
  • Debora Robba Division of Cardiology, Cremona Hospital, Italy.
  • Annunziata Cotugno Institute of Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Italy.
  • Meghi Dede University of Milan, Italy. https://orcid.org/0000-0002-9812-9173
  • Gian Battista Danzi Division of Cardiology, Cremona Hospital, Italy.


Spontaneous pneumomediastinum is a benign entity but can worsen the underlying condition with which it is associated. We evaluated the incidence and the clinical relevance of spontaneous pneumomediastinum in a consecutive series of 102 patients with COVID-19 pneumonia. Six cases of pneumomediastinum were identified by high-resolution chest CT-scan. Three patients required early intubation, and one of them died, while in in the remaining subjects the clinical course was benign. The presence of pneumomediastinum required some changes in the management of mechanical ventilation. In conclusion, spontaneous pneumomediastinum is a possible complication of severe COVID-19 pneumonia that can affect patient management and clinical outcomes.



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COVID-19 - Collection of articles on the Coronavirus outbreak
Conflict of interest statement
The study was approved by the Ethical Committee of Cremona Hospital
Pneumomediastinum, pneumonia, COVID-19
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How to Cite
Loffi, Marco, Valentina Regazzoni, Pietro Sergio, Enrico Martinelli, Italo Stifani, Filippo Quinzani, Debora Robba, Annunziata Cotugno, Meghi Dede, and Gian Battista Danzi. 2020. “Spontaneous Pneumomediastinum in COVID-19 Pneumonia”. Monaldi Archives for Chest Disease 90 (4). https://doi.org/10.4081/monaldi.2020.1399.

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