The impairment of the Growth Hormone/Insulin-like growth factor 1 (IGF-1) axis in heart failure: A possible target for future therapy

Submitted: June 19, 2018
Accepted: July 30, 2018
Published: September 5, 2018
Abstract Views: 1440
PDF: 995
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Hormonal abnormalities are quite common in chronic heart failure (CHF). The most studied hormonal axis in CHF is the impairment of Growth Hormone (GH)/Insulin Growth Factor-1(IGF-1), which in turn is defined either by a blunted response to GH stimulation test or low serum IGF-1 values.  Several independent groups reported that the presence of an abnormal GH/IGF-1 status in CHF is associated with a more severe disease, impaired functional capacity and reduced Survival rates. After the first encouraging results, double -blind controlled trials showed a neutral effect of the GH administration in patients. However, further studies reported positive results, when a GH-therapy is implemented only in those patients presenting a GH deficiency (replacement therapy).

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Piccioli, Lucrezia, Michele Arcopinto, Andrea Salzano, Roberta D’Assante, Alessandra Schiavo, Francesca M. Stagnaro, Anna Lombardi, et al. 2018. “The Impairment of the Growth Hormone Insulin-Like Growth Factor 1 (IGF-1) Axis in Heart Failure: A Possible Target for Future Therapy”. Monaldi Archives for Chest Disease 88 (3). https://doi.org/10.4081/monaldi.2018.975.

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