Letters to the Editor
Early Access
Successful pregnancy under benralizumab: a case of severe eosinophilic asthma
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Published: 11 March 2026
289
Views
159
Downloads
Authors
Dear Editor,
Monoclonal antibody therapy has revolutionized the management of eosinophilic disorders and severe asthma...
Downloads
Download data is not yet available.
Citations
Manetz S, Maric I, Brown T, et al. Successful pregnancy in the setting of eosinophil depletion by benralizumab. J Allergy Clin Immunol Pract 2021;9:1405-7.
Naftel J, Jackson D, Coleman M, et al. An international consensus on the use of asthma biologics in pregnancy. Lancet Respir Med 2025;13:80-91.
Ferguson GT, FitzGerald JM, Bleecker ER, et al. Benralizumab for patients with mild to moderate, persistent asthma (BISE): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Respir Med 2017;5:568-76.
Middleton PG, Gade EJ, Aguilera C, et al. ERS/TSANZ Task Force Statement on the management of reproduction and pregnancy in women with airways diseases. Eur Respir J 2020;55:1901208.
Ramos CL, Namazy J. Monoclonal antibodies (biologics) for allergic rhinitis, asthma, and atopic dermatitis during pregnancy and lactation. Immunol Allergy Clin North Am 2023;43:187-97.
Naftel J, Eames C, Kerley S, et al. Benralizumab treatment of severe asthma in pregnancy: a case series. J Allergy Clin Immunol Pract 2023;11:2919-21.
Russell MD, Dey M, Flint J, et al. British Society for Rheumatology guideline on prescribing drugs in pregnancy and breastfeeding: immunomodulatory anti-rheumatic drugs and corticosteroids. Rheumatology 2023;62:e48-88. Erratum in: Rheumatology 2023;62:2021.
Beltagy A, Aghamajidi A, Trespidi L, et al. Biologics during pregnancy and breastfeeding among women with rheumatic diseases: safety clinical evidence on the road. Front Pharmacol 2021;12:621247.
Saco T, Tabatabaian F. Breathing for two: a case of severe eosinophilic asthma during pregnancy treated with benralizumab. Ann Allergy Asthma Immunol 2018;121:S92.
Namazy J, Cabana MD, Scheuerle AE, et al. The Xolair Pregnancy Registry (EXPECT): the safety of omalizumab use during pregnancy. J Allergy Clin Immunol 2015;135:407-12.
Shakuntulla F, Chiarella SE. Safety of biologics for atopic diseases during pregnancy. J Allergy Clin Immunol Pract 2022;10:3149-55.
Jang W, Jo H, Park J, Kim S, et al. Use of biologics to treat asthma during pregnancy and adverse events in pregnant women and newborns: a global pharmacovigilance analysis. Int Arch Allergy Immunol 2025;186:875-88.
Wang D, Zhou X, Ning J, et al. Risk factors for neonatal hypoglycemia: a meta-analysis. BMC Endocr Disord 2024;24:166.
Aksu K, Yağdıran M, Çelik Tuğlu Het al. Mepolizumab and pregnancy: a case of severe eosinophilic asthma in a patient who conceived during mepolizumab treatment. Eurasian J Pulmonol 2025;27:62‑4.
How to Cite
“Successful Pregnancy under Benralizumab: A Case of Severe Eosinophilic Asthma”. 2026. Monaldi Archives for Chest Disease, March. https://doi.org/10.4081/monaldi.2026.3591.
Copyright (c) 2026 The Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.