Letters to the Editor Open access

Successful pregnancy under benralizumab: a case of severe eosinophilic asthma

Authors

Published
11 March 2026
Issue
Early Access
Section
Letters to the Editor
DOI
10.4081/monaldi.2026.3591

Abstract

Dear Editor,
Monoclonal antibody therapy has revolutionized the management of eosinophilic disorders and severe asthma...

Keywords

References

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  2. Naftel J, Jackson D, Coleman M, et al. An international consensus on the use of asthma biologics in pregnancy. Lancet Respir Med 2025;13:80-91.
  3. Ferguson GT, FitzGerald JM, Bleecker ER, et al. Benralizumab for patients with mild to moderate, persistent asthma (BISE): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Respir Med 2017;5:568-76.
  4. Middleton PG, Gade EJ, Aguilera C, et al. ERS/TSANZ Task Force Statement on the management of reproduction and pregnancy in women with airways diseases. Eur Respir J 2020;55:1901208.
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  9. Saco T, Tabatabaian F. Breathing for two: a case of severe eosinophilic asthma during pregnancy treated with benralizumab. Ann Allergy Asthma Immunol 2018;121:S92.
  10. Namazy J, Cabana MD, Scheuerle AE, et al. The Xolair Pregnancy Registry (EXPECT): the safety of omalizumab use during pregnancy. J Allergy Clin Immunol 2015;135:407-12.
  11. Shakuntulla F, Chiarella SE. Safety of biologics for atopic diseases during pregnancy. J Allergy Clin Immunol Pract 2022;10:3149-55.
  12. Jang W, Jo H, Park J, Kim S, et al. Use of biologics to treat asthma during pregnancy and adverse events in pregnant women and newborns: a global pharmacovigilance analysis. Int Arch Allergy Immunol 2025;186:875-88.
  13. Wang D, Zhou X, Ning J, et al. Risk factors for neonatal hypoglycemia: a meta-analysis. BMC Endocr Disord 2024;24:166.
  14. Aksu K, Yağdıran M, Çelik Tuğlu Het al. Mepolizumab and pregnancy: a case of severe eosinophilic asthma in a patient who conceived during mepolizumab treatment. Eurasian J Pulmonol 2025;27:62‑4.

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