Case Reports
Vol. 73 No. 2 (2010): Pulmonary series
https://doi.org/10.4081/monaldi.2010.305

Influenza A H1N1 pneumonia in a patient with hairy-cell leukemia

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Received: 19 January 2016
Published: 19 January 2016
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Influenza A H1N1 pneumonia, hairy cell leukemia, severe illness, prolonged course

Authors

A. Nicolini
antonello.nicolini@fastwebnet.it
Division of Respiratory Diseases, General Hospital, Sestri Levante, Genova, Italy.
A. Perazzo
Division of Respiratory Diseases, General Hospital, Sestri Levante, Genova, Italy.
Severe pandemic influenza A virus (H1N1) infection is associated with risk factors such as pregnancy, obesity and immunosuppression. Immunocompromised patients are at increased risk of more severe or prolonged infection. We report a case of a hairy cell leukemia patient with H1N1 pneumonia which caused severe and prolonged illness. H1N1 virus pneumonia with meticillin-resistant Staphilococcus Aerues (MRSA) coinfection causing Acute Lung Injury (ALI) was treated with a double-dose of osentamyvir, a high dose of teicoplanin and a low dose of corticosteroids. Haematological findings included leucopenia, neutropenia, lymphopenia, reduction of γ-globulins and natural killer (NK) cells. Reduction of NK and γ-globulins may explain the development of severe illness and the prolonged illness Neutropenia may explain the MRSA co-infection. Lymphopenia is directly associated with virus action and is considered to be a marker of the swine influenza in adults.

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“Influenza A H1N1 Pneumonia in a Patient With Hairy-Cell Leukemia”. 2016. Monaldi Archives for Chest Disease 73 (2). https://doi.org/10.4081/monaldi.2010.305.

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