https://doi.org/10.4081/monaldi.2023.2675
Tako-Tsubo syndrome in patients with COVID-19: a single centre retrospective case series
Submitted: June 29, 2023
Accepted: August 2, 2023
Published: September 5, 2023
Accepted: August 2, 2023
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Growing evidence shows that COVID-19 is associated with an increase in Tako-Tsubo syndrome (TTS) incidence. We collected data from patients hospitalized in our multidisciplinary COVID-19 department who had a diagnosis of TTS during the second and third wave of the pandemic in Italy. We reported four cases of TTS associated with COVID-19. No patient had any classical trigger for TTS except for COVID-19. Mean age was 72 years (67-81) and all patients had a SARS-CoV-2-related interstitial pneumonia confirmed by computed tomography. Typical apical ballooning and transitory reduction in left ventricle (LV) systolic function with a complete recovery before discharge were observed in all patients. The mean LV ejection fraction (LVEF) at TTS onset was 42% (40-48%). ECG showed ST-segment elevation in two cases, while an evolution with negative T waves and QTc prolongation was observed in all patients. Three patients underwent coronary angiography. Two patients had Alzheimer’s disease. The time interval from hospital admission to TTS onset was 4 (2-6) days, and the time interval from COVID-19 symptom onset to TTS diagnosis was 10 (8-12) days. COVID-19 may be a trigger for TTS, though TTS pathophysiology in COVID-19 patients remains unclear, likely due to its multifactorial nature.
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How to Cite
Alonzo, Alessandro, Stefania Angela Di Fusco, Lorenzo Castello, Andrea Matteucci, Antonella Spinelli, Gaetano Marino, Stefano Aquilani, Giuseppe Imperoli, and Furio Colivicchi. 2023. “Tako-Tsubo Syndrome in Patients With COVID-19: A Single Centre Retrospective Case Series”. Monaldi Archives for Chest Disease, September. https://doi.org/10.4081/monaldi.2023.2675.
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