https://doi.org/10.4081/monaldi.2023.2660
Sleep-disordered breathing and heart failure: a vicious cycle of cardiovascular risk
Submitted: June 11, 2023
Accepted: August 10, 2023
Published: September 1, 2023
Accepted: August 10, 2023
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Sleep-disordered breathing (SDB) represents an important cardiovascular risk factor that is still often underestimated and not always optimally treated. Such breathing disorders can induce several harmful effects on the heart, also favoring the development of arrhythmias, ischemic heart disease, and left ventricular remodeling. Obstructive sleep apnea syndrome (OSA) is more frequent in heart failure patients than in the general population, promoting the worsening of left ventricular dysfunction. Both sleep apnea and heart failure have common clinical manifestations but also similar neurohormonal characteristics, both contributing to the development and progression of heart failure and resulting in increased mortality. The pathophysiological mechanisms underlying left ventricular dysfunction associated with SDB will be analyzed, and the potential therapeutic effects of gliflozins on OSA in heart failure patients will be discussed.
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How to Cite
Cacciapuoti, Fulvio, Antonio D’Onofrio, Luca Gaetano Tarquinio, Valentina Capone, Ciro Mauro, Raffaele Marfella, and Federico Cacciapuoti. 2023. “Sleep-Disordered Breathing and Heart Failure: A Vicious Cycle of Cardiovascular Risk”. Monaldi Archives for Chest Disease, September. https://doi.org/10.4081/monaldi.2023.2660.
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