https://doi.org/10.4081/monaldi.2023.2654
Assessment of left ventricular function in subjects with chronic obstructive pulmonary disease
Submitted: June 5, 2023
Accepted: September 29, 2023
Published: October 16, 2023
Accepted: September 29, 2023
Abstract Views: 416
PDF_early view: 228
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Chronic obstructive pulmonary disease (COPD) is the world's third leading cause of death, posing a significant public health challenge. Heart failure is an important milestone in the natural history of this disease's ever-decreasing course. Cor pulmonale alone is sometimes insufficient to explain the scenario, as many heart failures are refractory even after standard treatment. A possible explanation is involvement of the left ventricle (LV). However, there is currently no consensus on a therapeutic approach to LV dysfunction in COPD. Some previous studies were conducted on COPD patients regardless of the presence or absence of other factors influencing LV function. This study attempted to rule out all known confounding factors/co-morbidities that influence LV function. We discovered that LV diastolic dysfunction was common in subjects at all stages of COPD. We believe that all COPD patients, regardless of stage, should have screening echocardiography.
GBD 2019 Diseases and Injuries Collaborators. Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet 2020 17;396:1204-22. Erratum in: Lancet 2020;396:1562.
Safiri S, Carson-Chahhoud K, Noori M, et al., Burden of chronic obstructive pulmonary disease and its attributable risk factors in 204 countries and territories, 1990-2019: results from the Global Burden of Disease Study 2019. BMJ 2022;378:e069679.
DOI: https://doi.org/10.1136/bmj-2021-069679
Jindal SK. COPD: The unrecognized epidemic in India. J Assoc Physicians India 2012;60:14-6.
Boussuges A, Pinet C, Molenat F, et al. Left atrial and ventricular filling in chronic obstructive pulmonary disease. An echocardiographic and Doppler study. Am J Respir Crit Care Med 2000;162:670-5.
DOI: https://doi.org/10.1164/ajrccm.162.2.9908056
Nootens M, Wolfkiel CJ, Chomka EV, Rich S. Understanding right and left ventricular systolic function and interactions at rest and with exercise in primary pulmonary hypertension. Am J Cardiol 1995;75:374-7.
DOI: https://doi.org/10.1016/S0002-9149(99)80557-8
Redfield MM, Jacobsen SJ, Borlaug BA, et al. Age- and gender-related ventricular-vascular stiffening: a community-based study. Circulation 2005;112:2254-62.
DOI: https://doi.org/10.1161/CIRCULATIONAHA.105.541078
Nagueh SF, Middleton KJ, Kopelen HA, et al. Doppler tissue imaging: a noninvasive technique for evaluation of left ventricular relaxation and estimation of filling pressures. J Am Coll Cardiol 1997;30:1527-33.
DOI: https://doi.org/10.1016/S0735-1097(97)00344-6
Kass DA. Ventricular arterial stiffening: integrating the pathophysiology. Hypertension 2005;46:185-93.
DOI: https://doi.org/10.1161/01.HYP.0000168053.34306.d4
Aldrich TK, Hendler JM, Vizioli LD, et al. Intrinsic positive end-expiratory pressure in ambulatory patients with airways obstruction. Am Rev Respir Dis 1993;147:845-9.
DOI: https://doi.org/10.1164/ajrccm/147.4.845
Laurent S, Cockcroft J, Van Bortel L, et al. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J 2006;27:2588-605.
DOI: https://doi.org/10.1093/eurheartj/ehl254
Kawaguchi M, Hay I, Fetics B, Kass DA. Combined ventricular systolic and arterial stiffening in patients with heart failure and preserved ejection fraction: implications for systolic and diastolic reserve limitations. Circulation 2003;107:714-20. Erratum in: Circulation 2020;141:e809.
DOI: https://doi.org/10.1161/01.CIR.0000048123.22359.A0
Curkendall SM, DeLuise C, Jones JK, et al. Cardiovascular disease in patients with chronic obstructive pulmonary disease, Saskatchewan Canada cardiovascular disease in COPD patients. Ann Epidemiol 2006;16:63-70.
DOI: https://doi.org/10.1016/j.annepidem.2005.04.008
Mattace-Raso FU, van der Cammen TJ, Hofman A, et al. Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study. Circulation 2006;113:657-63.
DOI: https://doi.org/10.1161/CIRCULATIONAHA.105.555235
Nishimura RA, Appleton CP, Redfield MM, et al. Noninvasive doppler echocardiographic evaluation of left ventricular filling pressures in patients with cardiomyopathies: a simultaneous Doppler echocardiographic and cardiac catheterization study. J Am Coll Cardiol 1996;28:1226-33.
DOI: https://doi.org/10.1016/S0735-1097(96)00315-4
Zvezdin B, Milutinov S, Kojicic M, et al. A postmortem analysis of major causes of early death in patients hospitalized with COPD exacerbation. Chest 2009;136:376-80.
DOI: https://doi.org/10.1378/chest.08-2918
Rawy AM, Fathalla D. Left ventricular diastolic dysfunction in patients with chronic obstructive pulmonary disease (COPD), prevalence and association with disease severity: Using tissue Doppler study. Egypt J Chest Dis Tubercul 2015;64:785-92.
DOI: https://doi.org/10.1016/j.ejcdt.2015.06.010
Vizza CD, Lynch JP, Ochoa LL, et al. Right and left ventricular dysfunction in patients with severe pulmonary disease. Chest 1998;113:576-83.
DOI: https://doi.org/10.1378/chest.113.3.576
Malerba M, Ragnoli B, Salameh M, et al. Sub-clinical left ventricular diastolic dysfunction in early stage of chronic obstructive pulmonary disease. J Biol Regul Homeost Agents 2011;25:443-51.
Steinberg BA, Zhao X, Heidenreich PA, et al. Trends in patients hospitalized with heart failure and preserved left ventricular ejection fraction: prevalence, therapies and outcomes. Circulation 2012;126:65-75.
DOI: https://doi.org/10.1161/CIRCULATIONAHA.111.080770
Steele P, Ellis JH, Van Dyke D, et al. Left ventricular ejection fraction in severe chronic obstructive airways disease. Am J Med 1975;59:21-8.
DOI: https://doi.org/10.1016/0002-9343(75)90317-4
Berger HJ, Matthay RA, Loke J, et al. Assessment of cardiac performance with quantitative radionuclide angiocardiography: right ventricular ejection fraction with reference to findings in chronic obstructive pulmonary disease. Am J Cardiol 1978;41:897-905.
DOI: https://doi.org/10.1016/0002-9149(78)90731-2
MacNee W, Xue QF, Hannan WJ, et al. Assessment by radionuclide angiography of right and left ventricular function in chronic bronchitis and emphysema. Thorax 1983;38:494-500.
DOI: https://doi.org/10.1136/thx.38.7.494
Zema MJ, Masters AP, Margouleff D. Dyspnea: the heart or the lungs? Differentiation at bedside by use of the simple Valsalva maneuver. Chest 1984;85:59-64.
DOI: https://doi.org/10.1378/chest.85.1.59
McCullough PA, Hollander JE, Nowak RM, et al. Uncovering heart failure in patients with a history of pulmonary disease: rationale for the early use of B-type natriuretic peptide in the emergency department. Acad Emerg Med 2003;10:198-204.
DOI: https://doi.org/10.1197/aemj.10.3.198
Ozben B, Eryuksel E, Tanrikulu AM, et al. Acute exacerbation impairs right ventricular function in COPD patients. Hellenic J Cardiol 2015;56:324-31.
Funk GC, Lang I, Schenk P, et al. Left ventricular diastolic dysfunction in patients with COPD in the presence and absence of elevated pulmonary arterial pressure. Chest 2008;133:1354-9.
DOI: https://doi.org/10.1378/chest.07-2685
Ethics approval
The study was approved by the Institutional Ethics Committee of KS Hegde Medical Academy which is a constituent institution of Nitte (Deemed to be University)How to Cite
Mupparapu, Murali, Rajesh Venkataram, Nandakishore Baikunje, Ivor D’sa, and Chandramouli Mandya Thimmaiah. 2023. “Assessment of Left Ventricular Function in Subjects With Chronic Obstructive Pulmonary Disease”. Monaldi Archives for Chest Disease, October. https://doi.org/10.4081/monaldi.2023.2654.
Copyright (c) 2023 The Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
