https://doi.org/10.4081/monaldi.2023.2640
Correlation between gastro-oesophageal reflux disease (GERD) lung volumes and exacerbation of bronchial asthma: Italian pilot observational retrospective study GERDAS
Submitted: May 16, 2023
Accepted: June 7, 2023
Published: June 15, 2023
Accepted: June 7, 2023
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Reflux asthma is an entity characterised by typical symptoms and in some cases is 'silent' and is more dangerous when associated with obesity and sleep apnoea syndrome. Its prevalence in the general population is high, as demonstrated by numerous studies listed below, and it is particularly a problem in the paediatric population; where, despite treatment by medical specialists, asthma symptoms are poorly controlled with a high risk of acute exacerbations. The aim of this clinical study is to show how the addition of a particular type of alginate (Deflux plus sachets) containing hyaluronic acid and melatonin at low doses administered over a prolonged period of six months, causes a reduction in vagal reflex stimulation of the oesophagus and pulmonary microaspiration reflexes by regulating lower oesophageal sphincter (LES) motility in asthmatic patients; improving the ACT score (asthma control test score). In the reported statistical analysis, ROC curves were performed for sensitivity and specificity for the analysed parameters, including the ACT score with statistically significant data p<0.0001. We conclude that the combination of conventional therapy for reflux asthma associated with alginates may improve the risk of acute asthma exacerbation and dynamic lung volumes.
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How to Cite
Scaramozzino, Marco Umberto, Maurizia Festa, Guido Levi, Ubaldo Romeo Plastina, and Giovanni Sapone. 2023. “Correlation Between Gastro-Oesophageal Reflux Disease (GERD) Lung Volumes and Exacerbation of Bronchial Asthma: Italian Pilot Observational Retrospective Study GERDAS”. Monaldi Archives for Chest Disease, June. https://doi.org/10.4081/monaldi.2023.2640.
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