Severe pneumonia after intravesical BCG instillation in a patient with invasive bladder cancer: case report and literature review

Submitted: November 26, 2015
Accepted: November 26, 2015
Published: November 26, 2015
Abstract Views: 1908
PDF: 915
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We present here the case of a 66 year old man with a severe bilateral community acquired pneumonia secondary to dissemination after an intravesical instillation of bacilllus Calmette-Guérin (BCG). Diagnosis was based on positive polymerase chain reaction (PCR) for mycobacterium tuberculosis complex in bronchoalveolar lavage and on the finding on transbronchial biopsy of non necrotising granulomas histopathologically similar to the granulomas found in bladder biopsies. These findings were confirmed using a validated real time PCR assay demonstrating the presence of the BCG genome in transbronchial and bladder biopsies.

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Caramori, G., D. Artioli, G. Ferrara, R. Cazzuffi, C. Pasquini, M. Libanore, V. Guardigni, I. Guzzinati, M. Contoli, R. Rossi, R. Rinaldi, C. Contini, and A. Papi. 2015. “Severe Pneumonia After Intravesical BCG Instillation in a Patient With Invasive Bladder Cancer: Case Report and Literature Review”. Monaldi Archives for Chest Disease 79 (1). https://doi.org/10.4081/monaldi.2013.109.