Pregabalin-induced first degree atrioventricular block in a young patient treated for pain from extrapulmonary tuberculosis

https://doi.org/10.4081/monaldi.2017.838

Authors

  • Alessandra Schiavo Federico II University School of Medicine, Italy.
  • Francesca M. Stagnaro Federico II University School of Medicine, Italy.
  • Andrea Salzano Federico II University School of Medicine, Italy. http://orcid.org/0000-0003-2352-2103
  • Alberto M. Marra IRCCS SDN, Italy.
  • Emanuele Bobbio Federico II University School of Medicine, Italy.
  • Pietro Valente Federico II University School of Medicine, Italy.
  • Simona Grassi Federico II University School of Medicine, Italy.
  • Martina Miniero Federico II University School of Medicine, Italy.
  • Michele Arcopinto Federico II University School of Medicine, Italy.
  • Margherita Matarazzo Federico II University School of Medicine, Italy.
  • Raffaele Napoli Federico II University School of Medicine, Italy.
  • Antonio Cittadini | cittadin@unina.it Federico II University School of Medicine, Italy. http://orcid.org/0000-0002-9905-9277

Abstract

Pregabalin, widely used in the treatment of several pain disorders, is usually well tolerated. Uncommonly, the drug may induce cardiac side effects, rarely prolongation of the PR interval. The latter has never been described in patients with healthy heart or normal renal function. We characterize a unique case of a young man with extrapulmonary tuberculosis and no detectable or known cardiac or kidney diseases, treated with pregabalin to control the severe pain due to the involvement of the spinal cord by the tuberculosis, showing an atrioventricular (AV) block due to pregabalin administration. The reported case emphasizes the need of monitoring PR interval during treatment with pregabalin, even in patients without background of cardiac or renal diseases. 

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Published
2017-09-28
Info
Issue
Section
Cardiology - Case Reports
Keywords:
Pregabalin, atrioventricular block, cardiovascular side effects, tuberculosis, pain.
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How to Cite
Schiavo, Alessandra, Francesca M. Stagnaro, Andrea Salzano, Alberto M. Marra, Emanuele Bobbio, Pietro Valente, Simona Grassi, Martina Miniero, Michele Arcopinto, Margherita Matarazzo, Raffaele Napoli, and Antonio Cittadini. 2017. “Pregabalin-Induced First Degree Atrioventricular Block in a Young Patient Treated for Pain from Extrapulmonary Tuberculosis”. Monaldi Archives for Chest Disease 87 (3). https://doi.org/10.4081/monaldi.2017.838.

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