Acebrophylline: an airway mucoregulator and anti-inflammatory agent

https://doi.org/10.4081/monaldi.2007.498

Authors

  • E. Pozzi | ernesto.pozzi@unipv.it Pulmonary Diseases Department, IRCCS San Matteo, University of Pavia, Italy.

Abstract

Acebrophylline is an airway mucus regulator with antiinflammatory action. The drug’s approach involves several points of attack in obstructive airway disease. The molecule contains ambroxol, which facilitates various steps in the biosynthesis of pulmonary surfactant, theophylline-7 acetic acid whose carrier function raises blood levels of ambroxol, thus rapidly and intensely stimulating surfactant production. The resulting reduction in the viscosity and adhesivity of the mucus greatly improves ciliary clearance. By deviating phosphatidylcholine towards surfactant synthesis, making it no longer available for the synthesis of inflammatory mediators such as the leukotrienes, acebrophylline also exerts an inflammatory effect. This is confirmed in vivo by the reduction in aspecific bronchial hyperresponsiveness in patients with stable bronchial asthma. On a clinical level, acebrophylline is therapeutically effective in patients with acute or chronic bronchitis, chronic obstructive or asthma-like bronchitis and recurrence of chronic bronchitis; it reduces the frequency of episodes of bronchial obstruction and reduces the need for β2-agonists, and improves indexes of ventilatory function.

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Published
2016-02-03
Info
Issue
Section
Reviews
Keywords:
Acebrophylline, ambroxol, alveolar surfactant, airway hyper-responsiveness, chronic bronchitis, asthma-like bronchitis
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How to Cite
Pozzi, E. 2016. “Acebrophylline: An Airway Mucoregulator and Anti-Inflammatory Agent”. Monaldi Archives for Chest Disease 67 (2). https://doi.org/10.4081/monaldi.2007.498.

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