Mortality among adult hospitalized patients during the first wave and second wave of COVID-19 pandemic at a tertiary care center in India

https://doi.org/10.4081/monaldi.2021.2034

Authors

  • Ravindra Nath Department of Community Medicine, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India. https://orcid.org/0000-0001-5082-935X
  • Neeraj Kumar Gupta Department of Pulmonary and Critical Care Medicine, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India.
  • Amandeep Jaswal Department of Anaesthesiology, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India.
  • Sparsh Gupta Department of Pharmacology, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India. https://orcid.org/0000-0003-0019-2690
  • Navjot Kaur Department of Pharmacology, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India.
  • Santvana Kohli Department of Anaesthesiology, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India.
  • Anirudh saxena Department of Community Medicine, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India.
  • Pranav Ish Department of Pulmonary and Critical Care Medicine, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India. https://orcid.org/0000-0003-1701-4970
  • Rohit Kumar Department of Pulmonary and Critical Care Medicine, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India. https://orcid.org/0000-0001-6398-7840
  • Poornima Tiwari Department of Community Medicine, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India. https://orcid.org/0000-0001-9817-396X
  • Mukesh Kumar Department of Pharmacology, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India.
  • Jugal Kishore Department of Community Medicine, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India.
  • Geeta Yadav Department of Community Medicine, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India.
  • Fellisha Marwein Department of Pulmonary and Critical Care Medicine, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India.
  • Nitesh Gupta | niteshgupta2107@gmail.com Department of Pulmonary and Critical Care Medicine, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India. https://orcid.org/0000-0002-5842-5584

Abstract

The similarities and differences between the mortality patterns of the two waves in India remain largely unknown. This was a retrospective study of medical records conducted in the COVID data center of our hospital This study analyzed data of patients who died in the month of August, 2020 to October 2020 (one month before and after the peak of first wave i.e., 16th September, 2020) & April 2021 to June 2021 (one month before and after the peak of second wave i.e., 6th May, 2021), corresponding to an equal part of the pandemic during first (2020) and second (2021) wave. Out of 1893 patients in the study, 764 patients were admitted during the first wave and 1129 patients during the second wave of pandemic. In total, 420 patients died during the entire study period. Of those, 147 (35%) deaths occurred during the first wave and 273 (65%) during the second wave, reflecting a case fatality rate (CFR) of 19.2% during the first wave and a CFR of 24.18%. There were no significant differences in the Age Group, Gender, Presenting Complaints, Duration of Stay and Comorbidities. However, the deceased COVID-19 patients had an increase in Case Fatality Rate, average duration of symptoms from onset to Hospital Admission (DOSHA) and a major shift from MODS to ARDS being the Cause of Death during the second wave of Pandemic. This study demonstrates increased CFR, average DOSHA and a paradigm shift to ARDS as cause of mortality during the second peak of the Pandemic. It is necessary to remain vigilant of newer COVID-19 variants of concern, follow COVID-19 appropriate behaviors and keep emphasizing on care of high-risk groups including patients with comorbidities and elderly population to prevent mortality.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

References

World Health Organization. Coronavirus disease (COVID-19) pandemic. Accessed on: 28th May, 2021. Available from: https://www.who.int/emergencies/diseases/novel-coronavirus-2019

Johns Hopkins University [Internet]. COVID-19 Data Repository by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University. Accessed on: 28th May, 2021. Available from: https://github.com/CSSEGISandData/COVID-19

Srivastava RK, Ish P, Covid-Vaccination Group S. The initial experience of COVID-19 vaccination from a tertiary care centre of India. Monaldi Arch Chest Dis 2021;1816. Online ahead of print. DOI: https://doi.org/10.4081/monaldi.2021.1816

Pandey V, Nazmi S. Covid-19 in India: Why second coronavirus wave is devastating. Accessed on: 28th May, 2021. Available from: https://www.bbc.com/news/world-asia-india-56811315

Iftimie S, López-Azcona AF, Vallverdú I, et al. First and second waves of coronavirus disease-19: A comparative study in hospitalized patients in Reus, Spain. PLoS One 2021;16 e0248029. DOI: https://doi.org/10.1101/2020.12.10.20246959

Stella GM, Piloni D, Coretti M, et al. Partition analysis of data of two waves of COVID-19 pandemic: is the landscape really evolving? A single institution experience. Minerva Med 2021. Online ahead of print.

Dorrucci M, Minelli G, Boros S, et al. Excess mortality in Italy during the COVID-19 pandemic: Assessing the differences between the first and the second wave, year 2020. Front Public Health 2021;9:669209. DOI: https://doi.org/10.3389/fpubh.2021.669209

Saito S, Asai Y, Matasunaga N, et al. First and second COVID-19 waves in Japan: A comparison of disease severity and characteristics. J Infect 2021;82:84–123. DOI: https://doi.org/10.1016/j.jinf.2020.10.033

Jalali SF, Ghassemzadeh M, Mouodi S, et al. Epidemiologic comparison of the first and second waves of coronavirus disease in Babol, North of Iran. Caspian J Intern Med 2020;11:s544-50.

Brehm TT, Heyer A, Roedl K, et al. Patient characteristics and clinical course of COVID-19 patients treated at a German tertiary center during the first and second waves in the year 2020. J Clin Med 2021;10:2274. DOI: https://doi.org/10.3390/jcm10112274

Ghani H, Navarra A, Pyae PK, et al. Relevance of prediction scores derived from the SARS-CoV-2 first wave, in the UK COVID-19 second wave, for early discharge, severity and mortality: a PREDICT COVID UK prospective observational cohort study. medRixv 2021.06.09.21258602. DOI: https://doi.org/10.1101/2021.06.09.21258602

Kunal S, Aditi, Gupta K, Ish P. COVID-19 variants in India: Potential role in second wave and impact on vaccination. Heart Lung 2021;50:784-7. DOI: https://doi.org/10.1016/j.hrtlng.2021.05.008

Gupta N, Ish P, Kumar R, et al. Evaluation of the clinical profile, laboratory parameters and outcome of two hundred COVID-19 patients from a tertiary centre in India. Monaldi Arch Chest Dis 2020;90:1507. DOI: https://doi.org/10.4081/monaldi.2020.1507

Ish P, Ish S. Prevention of mucormycosis in COVID-19 - the need of the hour. Indian J Ophthalmol 2021;69:1969. DOI: https://doi.org/10.4103/ijo.IJO_1200_21

Published
2021-10-11
Info
Issue
Section
COVID-19 - Collection of articles on the Coronavirus outbreak
Keywords:
COVID-19, Mortality, comorbidity, respiratory distress syndrome, multiple organ failure
Statistics
  • Abstract views: 91

  • PDF: 31
  • Supplementary Tables: 7
How to Cite
Nath, Ravindra, Neeraj Kumar Gupta, Amandeep Jaswal, Sparsh Gupta, Navjot Kaur, Santvana Kohli, Anirudh saxena, Pranav Ish, Rohit Kumar, Poornima Tiwari, Mukesh Kumar, Jugal Kishore, Geeta Yadav, Fellisha Marwein, and Nitesh Gupta. 2021. “Mortality Among Adult Hospitalized Patients During the First Wave and Second Wave of COVID-19 Pandemic at a Tertiary Care Center in India”. Monaldi Archives for Chest Disease, October. https://doi.org/10.4081/monaldi.2021.2034.

Most read articles by the same author(s)

1 2 3 > >>