N-3 polyunsaturated fatty acids reduces post-operative atrial fibrillation incidence in patients undergoing “on-pump†coronary artery bypass graft surgery

https://doi.org/10.4081/monaldi.2011.196

Authors

  • Mario Sorice Department of Cardiac Surgery, S. Anna e S. Sebastiano Hospital, Caserta, Italy.
  • Francesco Paolo Tritto | office@pagepress.org Department of Cardiac Surgery, S. Anna e S. Sebastiano Hospital, Caserta, Italy.
  • Chiara Sordelli Department of Cardiothoracic Sciences, Monaldi Hospital, Second University of Naples, Naples, Italy.
  • Rosario Gregorio Department of Cardiac Surgery, S. Anna e S. Sebastiano Hospital, Caserta, Italy.
  • Luigi Piazza Department of Cardiac Surgery, S. Anna e S. Sebastiano Hospital, Caserta, Italy.

Abstract

Background: The aim of this study was to evaluate the efficacy of preoperative and postoperative therapy with n-3 polyunsaturated fatty acids in reducing the incidence of atrial fibrillation after coronary artery bypass graft surgery. Methods: 201 patients undergoing coronary artery bypass graft surgery were randomized to 1) a control group (105 patients), or 2) n-3 polyunsaturated fatty acids 2 g/day group (96 patients) for at least 5 days before surgery and until hospital discharge. Groups were further subdivided in four subgroups according to the operative technique: “off-pump†or “on-pumpâ€. The primary end point was to evaluate the reduced incidence of postoperative in-hospital atrial fibrillation in the (N-3 PUFA) group. Secondary end points were the impact of the surgical technique on the incidence of postoperative arrhythmia and the impact of n-3 polyunsaturated fatty acids therapy on post-operative hospital length of stay. Results: The overall incidence of post-operative atrial fibrillation was 17.4% (35/201). The arrhythmia occurred in 11.4% (11/96) of the patients in therapy with n-3 polyunsaturated fatty acids and in 22.8% (24/105) in the control groups. In particular, the statistical analysis of subgroups showed a significant reduction of postoperative atrial fibrillation only in the group including patients treated with n-3 polyunsaturated fatty acids undergoing “on-pump†coronary artery bypass graft surgery. The length of hospital stay did not differ among all groups. Conclusions: N-3 polyunsaturated fatty acids administration significantly reduces the incidence of post-operative atrial fibrillation in patients undergoing “on-pump†coronary artery bypass graft surgery. N-3 polyunsaturated fatty acids therapy is not associated with a shorter hospital stay.

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Published
2015-12-09
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Section
Case Reports
Keywords:
heart bypass, coronary artery bypass, offpump, cardiopulmonary bypass, fatty acids, omega-3, atrial fibrillation.
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How to Cite
Sorice, Mario, Francesco Paolo Tritto, Chiara Sordelli, Rosario Gregorio, and Luigi Piazza. 2015. “N-3 Polyunsaturated Fatty Acids Reduces Post-Operative Atrial Fibrillation Incidence in Patients Undergoing “on-pump” Coronary Artery Bypass Graft Surgery”. Monaldi Archives for Chest Disease 76 (2). https://doi.org/10.4081/monaldi.2011.196.

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