From myocardium to the atherosclerotic plaque: new perspectives in cardiologic imaging

https://doi.org/10.4081/monaldi.2011.190

Authors

  • Paola Gargiulo Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università  degli Studi di Napoli Federico II, Italy.
  • Carmen D'Amore Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università  degli Studi di Napoli Federico II, Italy.
  • Santo Dellegrottaglie Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università  degli Studi di Napoli Federico II, Italy.
  • Dario Leosco Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università degli Studi di Napoli Federico II, Italy.
  • Giuseppe Rengo Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università  degli Studi di Napoli Federico II, Italy.
  • Francesca Musella Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università  degli Studi di Napoli Federico II, Italy.
  • Elisabetta Pirozzi Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università  degli Studi di Napoli Federico II, Italy.
  • Susanna Mosca Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università  degli Studi di Napoli Federico II, Italy.
  • Laura Casaretti Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università  degli Studi di Napoli Federico II, Italy.
  • Roberto Formisano Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università  degli Studi di Napoli Federico II, Italy.
  • Ada Bologna Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università  degli Studi di Napoli Federico II, Italy.
  • Antonio Parente Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università  degli Studi di Napoli Federico II, Italy.
  • Sirio Conte Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università  degli Studi di Napoli Federico II, Italy.
  • Pasquale Perrone-Filardi | fpperron@unina.it Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università  degli Studi di Napoli Federico II, Italy.

Abstract

Molecular imaging is an innovative and promising approach in cardiology for functional characterization of atherosclerosis. Nuclear, ultrasound and magnetic resonance imaging have been used for assessment of atherosclerosis of large and small arteries in several clinical and experimental studies. Positron Emission Tomography with fluorodeoxyglucose can measure metabolic activity and vulnerability of atherosclerotic plaques, identifying individuals at risk of future cardiovascular events. Magnetic resonance imaging can quantify carotid artery inflammation using iron oxide nanoparticles as contrast agent. In addition, macrophage accumulation of iron particles in atherosclerotic plaques may allow monitoring of inflammation during drug therapy, whereas contrast-enhanced ultrasound imaging may detect plaque neovascularization. Currently, technical factors, including cardiac and diaphragmatic motion and small size of coronary vessels, limit routine application of these techniques for coronary imaging. Purpose of this review is to describe state of the art and potential areas of clinical applications of molecular imaging of atherosclerosis.

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Published
2015-12-09
Info
Issue
Section
Reviews
Keywords:
atherosclerosis, molecular imaging, FDG PET, Magnetic Resonance Imaging, Ultrasound imaging
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  • PDF: 380
How to Cite
Gargiulo, Paola, Carmen D’Amore, Santo Dellegrottaglie, Dario Leosco, Giuseppe Rengo, Francesca Musella, Elisabetta Pirozzi, Susanna Mosca, Laura Casaretti, Roberto Formisano, Ada Bologna, Antonio Parente, Sirio Conte, and Pasquale Perrone-Filardi. 2015. “From Myocardium to the Atherosclerotic Plaque: New Perspectives in Cardiologic Imaging”. Monaldi Archives for Chest Disease 76 (2). https://doi.org/10.4081/monaldi.2011.190.

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