Pulmonary function, computerized tomography features and six-minute walk test at three months in severe COVID-19 patients treated with intravenous pulsed methylprednisolone: a preliminary report

https://doi.org/10.4081/monaldi.2021.1811

Authors

  • Cristiano van Zeller Department of Cardiothoracic Medicine and Department of Respiratory Medicine, St George’s University Hospital, London, United Kingdom. https://orcid.org/0000-0001-8289-0550
  • Asad Anwar Department of Cardiothoracic Medicine and Department of Intensive Care, St George’s University Hospital, United Kingdom. https://orcid.org/0000-0002-8493-6142
  • Nordita Ramos-Bascon Department of Cardiothoracic Medicine, St George’s University Hospital, United Kingdom.
  • Natalie Barnes Department of Cardiothoracic Medicine, St George’s University Hospital, United Kingdom.
  • Brendan Madden | Brendan.madden@stgeorges.nhs.uk Department of Cardiothoracic Medicine and Department of Intensive Care, St George’s University Hospital, United Kingdom. https://orcid.org/0000-0001-7768-9182

Abstract

COVID-19 ARDS has a high mortality and few therapeutic options. We present a preliminary report on our experience using high-dose pulsed methylprednisolone in COVID-19 ARDS and three-month outcomes. We performed a retrospective analysis of all patients treated with high-dose methylprednisolone for COVID-19 ARDS and three-month lung function, 6MWT, and CT findings. 15 patients were treated of which 10 survived to discharge. Reduced DLCO was the commonest abnormality in lung function tests and had the lowest mean value. Parenchymal bands were the commonest CT finding and 50% of patients had fibrosis at three-months. Mean 6MWD was 65.4% predicted and was abnormal in 62.5% of patients. In this cohort of patients with COVID-19 ARDS treated with high-dose methylprednisolone pulses, CT, lung function, and 6MWT abnormalities were unsurprisingly common at three months, although all 10 patients treated early in their disease course survived, a possible therapeutic effect. Further randomised controlled trials are needed to assess the benefits of this treatment.

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Published
2021-07-19
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Issue
Section
COVID-19 - Collection of articles on the Coronavirus outbreak
Keywords:
COVID-19, acute respiratory distress syndrome, pulmonary fibrosis, corticosteroids, lung function
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How to Cite
van Zeller, Cristiano, Asad Anwar, Nordita Ramos-Bascon, Natalie Barnes, and Brendan Madden. 2021. “Pulmonary Function, Computerized Tomography Features and Six-Minute Walk Test at Three Months in Severe COVID-19 Patients Treated With Intravenous Pulsed Methylprednisolone: A Preliminary Report”. Monaldi Archives for Chest Disease, July. https://doi.org/10.4081/monaldi.2021.1811.

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