Pulmonary embolism in patients with severe COVID-19 treated with intermediate- to full-dose enoxaparin: A retrospective study

https://doi.org/10.4081/monaldi.2021.1758

Authors

  • Cleante Scarduelli | cleante@libero.it ASST Mantova, Italy. https://orcid.org/0000-0003-3600-7653
  • Francesco Inglese ASST Mantova Italy, Italy. https://orcid.org/0000-0001-6467-8820
  • Massimiliano Beccaria Pulmonology and Respiratory Intensive Care Unit ASST Mantova , Italy. https://orcid.org/0000-0002-0901-4981
  • Fabio Speafico Pulmonology and Respiratory Intensive Care Unit ASST Mantova, Italy.
  • Martina Garuti Pulmonology and Respiratory Intensive Care Unit ASST Mantova, Italy.
  • Antonietta Pecoriello Pulmonology and Respiratory Intensive Care Unit ASST Mantova, Italy.
  • Giulia Cervi Pulmonology and Respiratory Intensive Care Unit ASST Mantova, Italy.
  • Graziana Greco Pulmonology and Respiratory Intensive Care Unit ASST Mantova, Italy. https://orcid.org/0000-0003-2887-0756
  • Sara Scarduelli Internal Medicine Department of Medical and Surgical Sciences Bologna University , Italy.
  • Giuseppe Lucchini Bio-statistical Service, ASST, Mantova, Italy.
  • Giuseppe De Donno Pulmonology and Respiratory Intensive Care Unit ASST Mantova, Italy.
  • Claudio Borghi Internal Medicine Department of Medical and Surgical Sciences Bologna University, Italy.

Abstract

Coronavirus disease (COVID-19) may predispose patients to pulmonary embolism (PE), despite standard thromboprophylaxis. Our retrospective study aimed to report the prevalence of PE in patients with COVID-19 and severe respiratory failure (SRF) treated with intermediate- to full-dose enoxaparin. We analyzed data from patients with COVID-19 pneumonia and SRF admitted to our Respiratory Intensive Care Unit (RICU) from February 27 to April 20, 2020. All patients received at least intermediate-dose enoxaparin (40 mg twice daily). Computed tomography pulmonary angiography (CTPA) was used to detect PE. Ninety-two patients with COVID-19 pneumonia and SRF were admitted to our RICU. Twenty-two patients underwent CTPA (24 %), 11 of whom had PEs (12%). We hypothesize that the enoxaparin treatment may be responsible for the lower prevalence of PE as compared to previous reports of similar patients, even if our report had several limitations, mainly the small sample size.

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References

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Published
2021-03-16
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Section
Pneumology - Original Articles
Keywords:
pulmonary embolism, venous thromboembolism, COVID-19, enoxaparin, respiratory failure
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How to Cite
Scarduelli, Cleante, Francesco Inglese, Massimiliano Beccaria, Fabio Speafico, Martina Garuti, Antonietta Pecoriello, Giulia Cervi, Graziana Greco, Sara Scarduelli, Giuseppe Lucchini, Giuseppe De Donno, and Claudio Borghi. 2021. “Pulmonary Embolism in Patients With Severe COVID-19 Treated With Intermediate- to Full-Dose Enoxaparin: A Retrospective Study”. Monaldi Archives for Chest Disease, March. https://doi.org/10.4081/monaldi.2021.1758.