Original Articles
Vol. 65 No. 1 (2006): Pulmonary series
https://doi.org/10.4081/monaldi.2006.581

Differential effect of cigarette smoking on hydrogen peroxide and thiobarbituric acid reactive substances exhaled in patients with community acquired pneumonia

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Received: 15 February 2016
Published: 15 February 2016
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Hydrogen peroxide, thiobarbituric acid reactive substances, cigarette smoking, reactive oxygen species, exhaled breath condensate, pneumonia

Authors

R.A. Stolarek
Department of Experimental and Clinical Physiology and Biochemistry, Medical University of Lodz, Poland.
M. Kasielski
Center of Medical Education, Practical Training Center, Medical University of Lodz, Poland.
J. Rysz
Department of Family Medicine, Medical University of Lodz, Poland.
P. Bialasiewicz
Department of Experimental and Clinical Physiology and Biochemistry, Medical University of Lodz, Poland.
D. Nowak
dnowak@zdn.am.lodz.pl
Department of Experimental and Clinical Physiology and Biochemistry, Medical University of Lodz, Poland.
Background. This study was designed to investigate the effect of cigarette smoking on hydrogen peroxide (H2O2) and thiobarbituric reactive substances (TBARs) concentrations in exhaled breath condensate (EBC) in patients with community acquired pneumonia (CAP). Methods. H2O2 and TBARs concentrations in EBC were determined with spectrofluorimetrical assays. Results. Non-smoking CAP patients (n=24) exhaled 1.4, 1.8 and 1.7 times more H2O2 than the smoking patients with CAP (n=19) as assessed one (0.73±0.32 μM v. 0.51±0.36 μM), three (0.84±0.31 μM v. 0.47±0.24 μM) and five (0.66±0.28 μM v. 0.40±0.35 μM) days after admission (p<0.05 in each case). Over 10 days of hospital treatment, mean level of exhaled H2O2 0.45±0.22 μM in CAP patients with smoking history was decreased if compared with 0.71±0.19 μM exhaled H2O2 in CAP group (p=0.005). On the contrary, TBARs concentration evaluated over entire study period was increased in smoking CAP patients (median 0.02 μM, range 0-0.32 μM) compared with non-smoking group (median 0.01 μM, range 0-0.21 μM, p<0.05). Concurrent, active smoking status was related with the decreased levels of H2O2 exhaled in breath condensate within the course of CAP but it appeared to increase levels of TBARs. Conclusions. The differential alternations of oxidative parameters in EBC with respect to the smoking status might provide evidence of increased H2O2 decomposition and enhanced generation of reactive species in airways of CAP patients.

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“Differential Effect of Cigarette Smoking on Hydrogen Peroxide and Thiobarbituric Acid Reactive Substances Exhaled in Patients With Community Acquired Pneumonia”. 2016. Monaldi Archives for Chest Disease 65 (1). https://doi.org/10.4081/monaldi.2006.581.

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