Cardiology - Original Articles Open access

Waist circumference and altered metabolic indices are associated with increased resting pulse rate in middle-aged adults

Authors

Published
10 January 2025
Section
Cardiology - Original Articles
DOI
10.4081/monaldi.2025.3205

Abstract

Metabolic indices significantly impact cardiovascular health. Research on the influence of metabolic indices on resting pulse rate in younger adults is needed. Utilizing the National Longitudinal Study of Adolescent to Adult Health (Add Health) Wave 5 public-use biological data, we performed a multiple linear regression analysis to determine the predictive factors of resting pulse rate in adults aged 32-42 years. We controlled for sex, anthropometrics, lipid indices, diabetic status, blood pressure, and antihypertensive use. The total number of participants was 1839 (weighted n=1,390,763), the mean age was 38.1 [standard deviation (SD)=2.0], and the mean pulse rate was 75.2 (SD=11.6). Notably, body mass index did not exhibit a statistically significant relationship with resting pulse rate. Conversely, females presented a statistically significantly higher pulse rate than males when adjusted for other variables [p<0.001; coefficient = 4.83; 95% confidence interval (CI): 3.54-6.13], as did individuals with increased waist circumference (p=0.023; coefficient = 2.62; 95% CI: 0.39-4.85). The data indicated a progressive rise in pulse rate correlating with elevated low-density lipoprotein and hemoglobin A1C levels, particularly among those with severe hypercholesterolemia (p=0.048, coefficient = 6.42; 95% CI: 0.12-12.71) and diabetes (p<0.001, coefficient = 7.11; 95% CI: 3.3-10.92). A significant increase was also observed in individuals with hypertension stage 1 and 2 [p<0.001 for both; coefficients = 2.98 (95% CI: 1.45-4.52) and 7.2 (95% CI: 5.28-9.12), respectively]. These findings underscore the necessity of considering metabolic indices in understanding the pathophysiology of elevated pulse rates in adults, thereby enhancing comprehension of cardiovascular tachyarrhythmias in younger adults.

Keywords

Ethics Approval

This research conducted a secondary analysis for publicly available, de-identified data, produced in compliance with the North Carolina Public Health Institutional Review Board (Chapel Hill, NC).

References

  1. Goorakani Y, Sedigh Rahimabadi M, Dehghan A, et al. Correlation of resting heart rate with anthropometric factors and serum biomarkers in a population-based study: fasa PERSIAN cohort study. BMC Cardiovasc Disord 2020;20:319. DOI: https://doi.org/10.1186/s12872-020-01594-y
  2. Ogliari G, Mahinrad S, Stott DJ, et al. Resting heart rate, heart rate variability and functional decline in old age. CMAJ 2015;187:E442-9. DOI: https://doi.org/10.1503/cmaj.150462
  3. Broman ME, Vincent JL, Ronco C, et al. The relationship between heart rate and body temperature in critically ill patients. Crit Care Med 2021;49:e327-31. DOI: https://doi.org/10.1097/CCM.0000000000004807
  4. Reimers AK, Knapp G, Reimers CD. Effects of exercise on the resting heart rate: a systematic review and meta-analysis of interventional studies. J Clin Med 2018;7:503. DOI: https://doi.org/10.3390/jcm7120503
  5. Costin A, Costin N, Cohen P, et al. Effect of exercise on heart-rate response to mental stress in teenagers. Eur J Prev Cardiol 2013;20:593-6. DOI: https://doi.org/10.1177/2047487312444369
  6. Schneider M, Kraemmer MM, Weber B, Schwerdtfeger AR. Life events are associated with elevated heart rate and reduced heart complexity to acute psychological stress. Biol Psychol 2021;163:108116. DOI: https://doi.org/10.1016/j.biopsycho.2021.108116
  7. Wang S, Fashanu OE, Zhao D, et al. Relation of elevated resting heart rate in mid-life to cognitive decline over 20 years (from the atherosclerosis risk in communities [ARIC] study). Am J Cardiol 2019;123:334-40. DOI: https://doi.org/10.1016/j.amjcard.2018.10.013
  8. Nanchen D, Stott DJ, Gussekloo J, et al. Resting heart rate and incident heart failure and cardiovascular mortality in older adults: role of inflammation and endothelial dysfunction: the PROSPER study. Eur J Heart Fail 2013;15:581-8. DOI: https://doi.org/10.1093/eurjhf/hfs195
  9. Ashour L, Ayesh L, Jarrar Z, et al. Altered anthropometrics and HA1c levels, but not dyslipidemia, are associated with elevated hs-CRP levels in middle-aged adults: a population-based analysis. Crit Pathw Cardiol 2024. doi:10.1097/HPC.0000000000000378 DOI: https://doi.org/10.1097/HPC.0000000000000378
  10. Whitsel, EA, Angel R, O’Hara R, et al. Add health wave v documentation: cardiovascular measures. 2020. Available from: https://doi.org/10.17615/gtme-ag52.
  11. Harris KM, Udry JR. National Longitudinal Study of Adolescent to Adult Health (Add Health), 1994-2018 [Public Use]. Available from. https://doi.org/10.3886/ICPSR21600.v25.
  12. Jing FY, Wang XL, Song JL, et al. Association between clustering of cardiovascular risk factors and resting heart rate in Chinese population: a cross-sectional study. J Geriatr Cardiol 2022;19:418-27.
  13. Freitas Júnior IF, Monteiro PA, Silveira LS, et al. Resting heart rate as a predictor of metabolic dysfunctions in obese children and adolescents. BMC Pediatr 2012;12:5. DOI: https://doi.org/10.1186/1471-2431-12-5
  14. Pal GK, Adithan C, Ananthanarayanan PH, et al. Sympathovagal imbalance contributes to prehypertension status and cardiovascular risks attributed by insulin resistance, inflammation, dyslipidemia and oxidative stress in first degree relatives of type 2 diabetics. PLoS One 2013;8:e78072. DOI: https://doi.org/10.1371/journal.pone.0078072
  15. Lambert E, Straznicky N, Sari CI, et al. Dyslipidemia is associated with sympathetic nervous activation and impaired endothelial function in young females. Am J Hypertens 2013;26:250-6. DOI: https://doi.org/10.1093/ajh/hps016
  16. Ikeda S, Shinohara K, Enzan N, et al. A higher resting heart rate is associated with cardiovascular event risk in patients with type 2 diabetes mellitus without known cardiovascular disease. Hypertens Res 2023;46:1090-9. DOI: https://doi.org/10.1038/s41440-023-01178-1
  17. Hadad R, Larsen BS, Weber P, et al. Night-time heart rate variability identifies high-risk people among people with uncomplicated type 2 diabetes mellitus. Diabet Med 2021;38:e14559. DOI: https://doi.org/10.1111/dme.14559
  18. Li Y, Deng B, Guo Y, et al. Correlation between glycosylated hemoglobin, ambulatory blood pressure and heart rate in patients with hypertension. Zhong Nan Da Xue Bao Yi Xue Ban 2021;46:488-96.
  19. Keshavarzi S, Braffett BH, Pop-Busui R, et al. Risk Factors for Longitudinal Resting Heart Rate and Its Associations With Cardiovascular Outcomes in the DCCT/EDIC Study. Diabetes Care 2021;44:1125-32. DOI: https://doi.org/10.2337/dc20-2387
  20. Hadad R, Akobe SF, Weber P, et al. Parasympathetic tonus in type 2 diabetes and pre-diabetes and its clinical implications. Sci Rep 2022;12:18020. DOI: https://doi.org/10.1038/s41598-022-22675-2
  21. Kamakura M, Maruyama R. Elevated HbA1c levels are associated with the blunted autonomic response assessed by heart rate variability during blood volume reduction. Tohoku J Exp Med 2016;240:91-100. DOI: https://doi.org/10.1620/tjem.240.91
  22. Kanagala A, M HJ. Metabolic dysregulation and its multifaceted impact on cardiovascular autonomic control in type 2 diabetes mellitus: insights from comprehensive assessment. Cureus 2024;16:e59776. DOI: https://doi.org/10.7759/cureus.59776
  23. Akasha R, Ahmad S, Abdeen R, et al. Linking elevated HbA1c with atherogenic lipid profile among high risk cardiovascular patients at Qassim, Saudi Arabia. Bioinformation 2024;20:212-6. DOI: https://doi.org/10.6026/973206300200212
  24. Kang P, Kim KY, Shin HY. Association between dyslipidemia and glycated hemoglobin in a population-based study. Metabolited 2024;14:92. DOI: https://doi.org/10.3390/metabo14020092
  25. Jalal DA, Vásárhelyi B, Blaha B, et al. Interrelationship of hemoglobin A1c level lipid profile, uric acid, C-reactive protein levels and age in a large hospital database. Mol Cell Probes 2023;72:101933. DOI: https://doi.org/10.1016/j.mcp.2023.101933
  26. Yadav RL, Yadav PK, Yadav LK, et al. Association between obesity and heart rate variability indices: an intuition toward cardiac autonomic alteration - a risk of CVD. Diabetes Metab Syndr Obes 2017;10:57-64. DOI: https://doi.org/10.2147/DMSO.S123935
  27. Ross R, Neeland IJ, Yamashita S, et al. Waist circumference as a vital sign in clinical practice: a Consensus Statement from the IAS and ICCR Working Group on Visceral Obesity. Nat Rev Endocrinol 2020;16:177-89. DOI: https://doi.org/10.1038/s41574-019-0310-7
  28. Wenting W, Yeran J, Wenfeng Z, et al. Increased resting heart rate and glucose metabolism in a community population. J Int Med Res 2021;49:3000605211053754. DOI: https://doi.org/10.1177/03000605211053754
  29. Quer G, Gouda P, Galarnyk M, et al. Inter- and intraindividual variability in daily resting heart rate and its associations with age, sex, sleep, BMI, and time of year: retrospective, longitudinal cohort study of 92,457 adults. PLoS One 2020;15:e0227709. DOI: https://doi.org/10.1371/journal.pone.0227709
  30. Christofaro DGD, Casonatto J, Vanderlei LCM, et al. Relationship between resting heart rate, blood pressure and pulse pressure in adolescents. Arq Bras Cardiol 2017;108:405-10. DOI: https://doi.org/10.5935/abc.20170050
  31. Shen L, Wang Y, Jiang X, et al. Dose-response association of resting heart rate and hypertension in adults: a systematic review and meta-analysis of cohort studies. Medicine 2020;99:e19401. DOI: https://doi.org/10.1097/MD.0000000000019401
  32. Goonasekara CL, Balse E, Hatem S, et al. Cholesterol and cardiac arrhythmias. Expert Rev Cardiovasc Ther 2010;8:965-79. DOI: https://doi.org/10.1586/erc.10.79
  33. Grisanti LA. Diabetes and arrhythmias: pathophysiology, mechanisms and therapeutic outcomes. Front Physiol 2018;9:1669. DOI: https://doi.org/10.3389/fphys.2018.01669
  34. Lip GYH, Coca A, Kahan T, et al. Hypertension and cardiac arrhythmias: a consensus document from the European Heart Rhythm Association (EHRA) and ESC Council on Hypertension, endorsed by the Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS) and Sociedad Latinoamericana de Estimulación Cardíaca y Electrofisiología (SOLEACE). Europace 2017;19:891-911. DOI: https://doi.org/10.1093/europace/eux091
  35. Zeitler EP, Poole JE, Albert CM, et al. Arrhythmias in female patients: incidence, presentation and management. Circ Res 2022;130:474-95. DOI: https://doi.org/10.1161/CIRCRESAHA.121.319893

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