Additional yield of transbronchial cryo‐node biopsy over endobronchial ultrasound-guided transbronchial needle aspiration for mediastinal lesions at a tertiary care center in India (COLD-FORCEPS-2 study)
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Accepted: 3 June 2024
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Endobronchial ultrasound (EBUS)-guided mediastinal cryobiopsy is a new modality for sampling mediastinal lymph nodes. The data regarding the diagnostic yield and utility of mediastinal cryobiopsy is still limited. Consecutive patients who were undergoing EBUS-guided transbronchial needle aspiration (EBUS-TBNA) were recruited in this study. We subjected the enrolled patients to EBUS-guided mediastinal cryobiopsy after obtaining their informed consent. The final diagnosis was made with a clinical-pathological-radiological assessment and clinical-radiological follow-up. A total of 101 patients were enrolled in the study. Adequacy in sampling achieved in EBUS-TBNA was 92.07%, compared to 98.01% achieved in EBUS-TBNA with mediastinal cryobiopsy. Diagnostic yields achieved in EBUS-TBNA and EBUS-TBNA with mediastinal cryobiopsy were 67.32% and 86.13%, respectively (p=0.001). EBUS patterns failed to predict the utility of mediastinal cryobiopsy. No significant complications were observed. To conclude, EBUS-guided mediastinal cryobiopsy improves yield in patients undergoing EBUS-TBNA.
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Institute ethical committee clearance taken vide S. No. IEC/VMMC/SJH/Project 2024-01/429 dated 4 March 2024.How to Cite
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