https://doi.org/10.4081/monaldi.2024.2991

Hematological and clinical profiling of chronic obstructive pulmonary disease: a comprehensive study

Early Access
Submitted: March 14, 2024
Accepted: August 9, 2024
Published: September 30, 2024
COPD, hemoglobin, erythrocytosis, polycythemia, anemia, pulmonary function
Abstract Views: 123
PDF_EARLY VIEW: 46
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

Amit Sharma
Department of Tuberculosis and Respiratory Diseases, National Institute of Tuberculosis and Respiratory Disease, New Delhi, India.
Deepak Rathi
Department of Tuberculosis and Respiratory Diseases, National Institute of Tuberculosis and Respiratory Disease, New Delhi, India.
Prerna Jain
https://orcid.org/0000-0003-2407-2167
Department of Biochemistry, National Institute of Tuberculosis and Respiratory Disease, New Delhi, India.
Devika Tayal
d.tayal@nitrd.nic.in
https://orcid.org/0000-0001-6821-7677
Department of Biochemistry, National Institute of Tuberculosis and Respiratory Disease, New Delhi, India.

Chronic obstructive pulmonary disease (COPD) presents as a multifaceted clinical landscape with various hematological manifestations. Among these, polycythemia and anemia pose distinct challenges. While the prevalence of polycythemia has decreased in recent years, anemia remains a prevalent concern, impacting patient outcomes. This study investigated the incidence and clinical characteristics of polycythemia in COPD patients, focusing on a diverse cohort in India. Methodological approaches included comprehensive evaluations of clinical parameters, pulmonary function, and hematological profiles. Results revealed significant variations in COPD severity, pulmonary function, and respiratory symptoms among patients with different hemoglobin levels. The findings shed light on the complex interplay between hematological variations and clinical manifestations in COPD, providing valuable insights for disease management strategies.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

Crossref
Scopus
Google Scholar
Europe PMC
Agustí A, Celli BR, Criner GJ, et al. Global initiative for chronic obstructive lung disease 2023 report: GOLD executive summary. Am J Respirat Crit Care Med 2023;207:819-37. DOI: https://doi.org/10.1164/rccm.202301-0106PP
Vlahakos V, Marathias K, Lionaki S, et al. The paradigm shift from polycythemia to anemia in COPD: the critical role of the renin–angiotensin system inhibitors. Expert Rev Respir Med 2022;16:391-8. DOI: https://doi.org/10.1080/17476348.2022.2045958
Kollert F, Tippelt A, Müller C, et al. Hemoglobin levels above anemia thresholds are maximally predictive for long-term survival in COPD with chronic respiratory failure. Respir Care 2013;58:1204-12. DOI: https://doi.org/10.4187/respcare.01961
Shujaat A, Minkin R, Eden E. Pulmonary hypertension and chronic cor pulmonale in COPD. Int J Chron Obstruct Pulmon Dis 2007;2:273-82.
Chambellan A, Chailleux E, Similowski T. Prognostic value of the hematocrit in patients with severe COPD receiving long-term oxygen therapy. Chest 2005;128:1201-8. DOI: https://doi.org/10.1378/chest.128.3.1201
Alkhedaide AQ. Tobacco smoking causes secondary polycythemia and a mild leukocytosis among heavy smokers in Taif City in Saudi Arabia. Saudi J Biol Sci 2020;27:407-11. DOI: https://doi.org/10.1016/j.sjbs.2019.11.001
McMullin M, Harrison C, Ali S, et al. A guideline for the diagnosis and management of polycythaemia vera. A British Society for Haematology Guideline. Br J Haematol 2018;184:176-91. DOI: https://doi.org/10.1111/bjh.15648
Rimal S, Das SK, Basnet A, et al. Prevalence and clinical impact of anemia in patients diagnosed with chronic obstructive pulmonary disease: a cross‐sectional study. Health Sci Rep 2023;6:e1371. DOI: https://doi.org/10.1002/hsr2.1371
Balasubramanian A, Henderson RJ, Putcha N, et al. Haemoglobin as a biomarker for clinical outcomes in chronic obstructive pulmonary disease. ERJ Open Res 2021;7:00068-2021. DOI: https://doi.org/10.1183/23120541.00068-2021
Ganesh M S, Satheesh S, Aravindhan S. Insights into the pathophysiology and therapeutic targets of consequences induced by polycythemia in COPD. Biotech Res Asia 2023;20. DOI: https://doi.org/10.13005/bbra/3170
Zielinski J, Tobiasz M, Hawrylkiewicz I, et al. Effects of long-term oxygen therapy on pulmonary hemodynamics in COPD patients: a 6-year prospective study. Chest 1998;113:65-70. DOI: https://doi.org/10.1378/chest.113.1.65
Zhang J, DeMeo DL, Silverman EK, et al. Secondary polycythemia in chronic obstructive pulmonary disease: prevalence and risk factors. BMC Pulm Med 2021;21:235. DOI: https://doi.org/10.1186/s12890-021-01585-5
Masa JF, Pépin JL, Borel JC, et al. Obesity hypoventilation syndrome. Eur Respir Rev 2019;28:180097. DOI: https://doi.org/10.1183/16000617.0097-2018
Semenza GL. Regulation of oxygen homeostasis by hypoxia-inducible factor 1. Physiology 2009;24:97-106. DOI: https://doi.org/10.1152/physiol.00045.2008
Pahal P, Hashmi MF, Sharma S. Chronic obstructive pulmonary disease compensatory measures. Treasure Island, FL, USA: StatPearls Publishing; 2024.
Sarkar M, Rajta PN, Khatana J. Anemia in chronic obstructive pulmonary disease: prevalence, pathogenesis, and potential impact. Lung India 2015;32:142-51. DOI: https://doi.org/10.4103/0970-2113.152626
Kayrak M, Acar K, Gul EE, et al. Electrocardiographic findings in patients with polycythemia vera. Int J Med Sci 2012;9:93-102. DOI: https://doi.org/10.7150/ijms.9.93

Ethics approval

This study was approved by Institute Ethics Committee. All the patients were recruited in the study only after obtaining proper consent from the patients or their representatives (NITRD/PGEC/2019/5172).

How to Cite

Sharma, Amit, Deepak Rathi, Prerna Jain, and Devika Tayal. 2024. “Hematological and Clinical Profiling of Chronic Obstructive Pulmonary Disease: A Comprehensive Study”. Monaldi Archives for Chest Disease, September. https://doi.org/10.4081/monaldi.2024.2991.
Copyright (c) 2024 The Author(s) Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.