https://doi.org/10.4081/monaldi.2023.2652

Utility of systemic immune-inflammation Index as a serum biomarker to differentiate between complicated and simple para-pneumonic effusion

Early Access
Submitted: June 2, 2023
Accepted: August 28, 2023
Published: September 7, 2023
Pneumonia, parapneumonic effusion, systemic immune-inflammation index
Abstract Views: 490
PDF_early view: 270
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

Nikhil Rajvanshi
https://orcid.org/0000-0002-0787-8815
Department of Pediatrics, All India Institute of Medical Sciences, Jodhpur, India.
Prawin Kumar
https://orcid.org/0000-0002-2365-8097
Department of Pediatrics, All India Institute of Medical Sciences, Jodhpur, India.
Jagdish Prasad Goyal
jpgoyal@rediffmail.com
https://orcid.org/0000-0002-7198-6909
Department of Pediatrics, All India Institute of Medical Sciences, Jodhpur, India.

The systemic immune-inflammation index (SII) is a novel inflammatory biomarker. Simple and complicated para-pneumonic effusion (PPE) are two significant complications of pneumonia. We evaluated the efficacy of the systemic immune inflammation index (SII) to differentiate between the two. Records of all children up to 18 years of age admitted between April 2019 and September 2022 and diagnosed with Simple or complicated PPE were retrospectively evaluated. SII and other biomarkers were compared between both groups. ROC with the Youden index was used to estimate the discriminative value of SII. Fifty children were enrolled with a median (IQR) age of 81.5 (36.7, 133.5) months; 31 (62%) were male. Thirty-one (62%) had complicated PPE, and 19 (38%) had simple PPE. SII was significantly higher in complicated PPE (p=0.007). Good areas under the curve (AUCs) were found for CRP (0.771) and SII (0.736) to differentiate complicated from simple PPE. The best cut-off value for SII to differentiate complicated PPE from simple PPE was 1557×103µL, with a sensitivity of 82.4% and specificity of 57.6%. SII can be used as a screening tool to differentiate between complicated and simple PPE at the time of presentation.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

Crossref
Scopus
Google Scholar
Europe PMC
Wolrd Health Organization. Pneumonia in children. Available from: https://www.who.int/news-room/fact-sheets/detail/pneumonia
Sahn SA. Diagnosis and management of parapneumonic effusions and empyema. Clin Infect Dis 2007;45:1480-6. DOI: https://doi.org/10.1086/522996
Light RW. Parapneumonic effusions and empyema. Proc Am Thorac Soc 2006;3:75-80. DOI: https://doi.org/10.1513/pats.200510-113JH
Güneylioğlu MM, Güngör A, Göktuğ A, et al. Evaluation of the efficiency of the systemic immune-inflammation index in differentiating parapneumonic effusion from empyema. Pediatr Pulmonol 2022;57:1625-30. DOI: https://doi.org/10.1002/ppul.25926
Bradley JS, Byington CL, Shah SS, et al. The Management of community-acquired pneumonia in infants and children older than 3 months of age: clinical practice guidelines by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America. Clin Infect Dis 2011;53:e25-76. DOI: https://doi.org/10.1093/cid/cir531
Florin TA, Ambroggio L, Brokamp C, et al. Biomarkers and disease severity in children with community-acquired pneumonia. Pediatrics 2020;145:e20193728. DOI: https://doi.org/10.1542/peds.2019-3728
Lahti E, Peltola V, Virkki R, et al. Development of parapneumonic empyema in children. Acta Paediatr 2007;96:1686-92. DOI: https://doi.org/10.1111/j.1651-2227.2007.00511.x
Hu B, Yang XR, Xu Y, et al. Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma. Clin Cancer Res 2014;20:6212-22. DOI: https://doi.org/10.1158/1078-0432.CCR-14-0442
Calkins CM, St Peter SD, Holcomb GW, III. Empyema. In: L. Spitz and A.G. Coran, editors. Operative Pedratic Surgery. Boca Raton: CRC Press; 2022. p. 217-24.
Sevinc C, Demirci R, Timur O. Predicting hospital mortality in COVID-19 hemodialysis patients with developed scores. Semin Dial 2021;34347-59. DOI: https://doi.org/10.1111/sdi.13004
Patel KM, Ullah K, Patail H, Ahmad S. Ultrasound for pleural disease: Beyond a pocket of pleural fluid. Ann Am Thorac Soc 2021;18:749-56. DOI: https://doi.org/10.1513/AnnalsATS.202008-948CME
Saricam M. Efficiency of lymphocyte-to-monocyte ratio in differential diagnosis of parapneumonic effusion and thoracic empyema. Surg Infect (Larchmt) 2020;21:891-4. DOI: https://doi.org/10.1089/sur.2019.346
Li D, Shen Y, Qin J, et al. Diagnostic performance of C-reactive protein for parapneumonic pleural effusion: a meta-analysis. Ann Transl Med 2019;7:1. DOI: https://doi.org/10.21037/atm.2018.11.44

Ethics approval

The study protocol was approved by the Ethical Review Committee of the All India Institute of Medical Sciences, Jodhpur, India

How to Cite

Rajvanshi, Nikhil, Prawin Kumar, and Jagdish Prasad Goyal. 2023. “Utility of Systemic Immune-Inflammation Index As a Serum Biomarker to Differentiate Between Complicated and Simple Para-Pneumonic Effusion”. Monaldi Archives for Chest Disease, September. https://doi.org/10.4081/monaldi.2023.2652.
Copyright (c) 2023 The Author(s) Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.