Rhabdomyolysis induced by co-administration of fluvastatin and colchicine

Submitted: December 23, 2015
Accepted: December 23, 2015
Published: December 23, 2015
Abstract Views: 1017
PDF: 784
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A case of fluvastatin-induced rhabdomyolysis after coadministration of colchicine is reported. A 77 year old man with ischemic heart disease, chronic pericardial effusion, diabetes mellitus, dyslipidemia, arterial hypertension, chronic renal failure (stage 2 of classification of chronic kidney disease of National Kidney Foundation) and chronic gout presented with a generalized muscle pain. The patient had been taking 80 mg/day of fluvastatin for 4 years, and, for four weeks before presentation, he had also been taking a dose of colchicine (1.0 mg daily) for an exacerbation of gout. Investigations confirmed the diagnosis of rhabdomyolysis. Discontinuation of fluvastatin and colchicine therapy and adequate fluid administration resulted in the resolution of clinical and biochemical features of rhabdomyolysis. Although neuromuscular adverse effects of fluvastatin and colchicine are well recognized, rhabdomyolysis is rare, making this is only the second case reported of fluvastatin and colchicine co-administration induced rhabdomyolysis in literature.

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How to Cite

Sarullo, Filippo M., Luigi Americo, Antonino Di Franco, and Pietro Di Pasquale. 2015. “Rhabdomyolysis Induced by Co-Administration of Fluvastatin and Colchicine”. Monaldi Archives for Chest Disease 74 (3). https://doi.org/10.4081/monaldi.2010.264.

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