Laboratory and demographic findings among patients with coronavirus disease 2019: A review

https://doi.org/10.4081/monaldi.2021.1694

Authors

  • Atefeh Mir Clinical Research Center of Sabzevar Vasei Hospital, Sabzevar University of Medical Sciences, Sabzevar, Iran, Islamic Republic of. https://orcid.org/0000-0001-6666-1379
  • Khadijeh Kalan Farmanfarma Department of Epidemiology, Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran, Islamic Republic of. https://orcid.org/0000-0002-4663-6616
  • Hamid Salehiniya Social Determinants of Health Research Center, Birjand University of Medical Sciences, Birjand, Iran, Islamic Republic of. https://orcid.org/0000-0001-7642-5214
  • Abolfazl Shakiba Department of Internal Medicine, School of Medicine, Leishmaniasis Research Center, Vasei Hospital, Sabzevar University of Medical Sciences, Sabzevar, Iran, Islamic Republic of.
  • Neda Mahdavifar | n.mahdavifar90@gmail.com Department of Biostatistics and Epidemiology, School of Health, NonCommunicable Diseases Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran, Islamic Republic of. https://orcid.org/0000-0002-5764-7978

Abstract

Coronavirus disease 2019 (COVID-19) is the third known animal coronavirus, after severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome coronavirus (MERS-CoV). The mean age of the infected patients was estimated to be between 50 and 69 years old. Accordingly, the COVID-19 mortality rate was calculated as 15%. In this regard, the essential component of prevention and planning is knowledge of laboratory and demographic findings among COVID-19 patients; therefore, the present study was conducted to investigate laboratory and demographic findings among these patients worldwide. This systematic review was performed on the articles published in English between January 1, 2019 and May 4, 2020, using MeSH-compliant keywords such as "COVID-19", "Laboratory, coronavirus disease-19 testing", and " demography " in international databases (PubMed, and web of science Scopus). Thereafter, the articles relevant to laboratory and demographic findings among COVID-19 patients were included in the final review. Reviewing the included articles showed changes in the mean lymphocytes count ranged from 0.7 to 39 in hospital or severe cases. Moreover, Leukopenia was not observed in patients with thrombocytopenia. In addition, C-reactive protein (CRP), leukocytes, D-dimer, FDP, FIB, neutrophils, AST, serum creatinine, t-troponin, troponin I, and blood bilirubin levels showed increasing trends in most studies conducted on COVID-19 patients. Notably, the elevated LDH level was more common among children than adults. According to the results of the present study, and by considering the clinical characteristics of COVID-19 patients on the one hand, and considering the changes in laboratory samples such as lymphocytes and other blood markers due to the damaged myocardial, hepatic, and renal tissues on the other hand, it is recommended to confirm the diagnosis of this infection by evaluating the patients’ blood samples using other diagnostic methods like lung scan.

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Published
2021-07-14
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COVID-19 - Collection of articles on the Coronavirus outbreak
Keywords:
Keywords: COVID-19, Laboratory finding , Systematic reviews
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How to Cite
Mir, Atefeh, Khadijeh Kalan Farmanfarma, Hamid Salehiniya, Abolfazl Shakiba, and Neda Mahdavifar. 2021. “Laboratory and Demographic Findings Among Patients With Coronavirus Disease 2019: A Review”. Monaldi Archives for Chest Disease, July. https://doi.org/10.4081/monaldi.2021.1694.

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