TY - JOUR AU - Garcia-Olivé, Ignasi AU - Sintes, Helena AU - Radua, Joaquim AU - Deportos, Jordi AU - Nogueira, Isabel AU - Morales-Indiano, Cristian AU - Abad Capa, Jorge AU - Rosell, Antoni PY - 2021/03/11 Y2 - 2024/03/29 TI - Predicting pulmonary embolism in patients infected with COVID-19 based on D-dimer levels and days between diagnosis of the infection and D-dimer determination JF - Monaldi Archives for Chest Disease JA - Monaldi Arch Chest Dis VL - 91 IS - 2 SE - Pneumology - Original Articles DO - 10.4081/monaldi.2021.1622 UR - https://www.monaldi-archives.org/macd/article/view/1622 SP - AB - <p>Ruling out pulmonary embolism (PE) can be challenging in a situation of elevated D-dimer values such as in a case of COVID-19 infection. Our objective was to evaluate the difference in D-dimer values of subjects infected with COVID-19 in those with PE and those without and to analyze the predictive value of D-dimer for PE in these subjects based on the day of D-dimer determination. This was an observational, retrospective study, conducted at a tertiary hospital. All subjects with PCR-confirmed COVID-19 infection requiring hospital admission at our institution between the months of March and April 2020 were included in the study. We compared D-dimer levels in subjects who went on to develop a PE and those who did not. We then created a model to predict the subsequent development of a PE with the current D-dimer levels of the subject. D-dimer levels changed over time from COVID-19 diagnosis, but were always higher in subjects who went on to develop a PE. Regarding the predictive model created, the area under the curve of the ROC analyses of the cross-validation predictions was 0.72. The risk of pulmonary embolism for the same D-dimer levels varied depending on the number of days elapsed since COVID-19 diagnosis and D-dimer determination. To conclude, D-dimer levels were elevated in subjects with a COVID-19 infection, especially in those with PE. D-dimer levels increased during the first 10 days after the diagnosis of the infection and can be used to predict the risk of PE in COVID-19 subjects.</p> ER -