New perspectives in cardiovascular risk reduction: focus on HDL

Stefania Paolillo, Giuseppe Luca Della Ratta, Alice Vitagliano, Annapaola Cirillo, Elisabetta Lardino, Tiziana Formisano, Irma Fabiani, Angela Maria Pellegrino, Pietro Riello, Pasquale Perrone Filardi
  • Stefania Paolillo
    Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy
  • Giuseppe Luca Della Ratta
    Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy
  • Alice Vitagliano
    Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy
  • Annapaola Cirillo
    Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy
  • Elisabetta Lardino
    Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy
  • Tiziana Formisano
    Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy
  • Irma Fabiani
    Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy
  • Angela Maria Pellegrino
    Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy
  • Pietro Riello
    Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy
  • Pasquale Perrone Filardi
    Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy | fpperron@unina.it

Abstract

Cardiovascular diseases represent the leading cause of morbidity and mortality worldwide, mostly contributing to hospitalizations and health care costs. Dyslipidemias represent one of the major cardiovascular risk factor and its management, throughout life-style modifications and pharmacological interventions, has shown to reduce cardiac events. The risk of adverse cardiovascular events is related not only to elevated LDL blood levels, but also to decreased HDL concentrations, that exhibit protective effects in the development of atherosclerotic process. Aim of this review is to summarize current evidences about defensing effects of such lipoproteins and to show the most recent pharmacological strategies to reduce cardiovascular risk through the increase of their circulating levels.

Keywords

dyslipidemia, HDL, cardiovascular risk

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Submitted: 2015-11-25 14:05:59
Published: 2015-11-25 14:35:39
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Copyright (c) 2015 Stefania Paolillo, Giuseppe Luca Della Ratta, Alice Vitagliano, Annapaola Cirillo, Elisabetta Lardino, Tiziana Formisano, Irma Fabiani, Angela Maria Pellegrino, Pietro Riello, Pasquale Perrone Filardi

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